scholarly journals Inhibition of cell proliferation by 2-fluorobenzaldehyde retinoic acid conjugate through suppression of STAT3 activation in human glioma cells

2015 ◽  
Vol 10 (4) ◽  
pp. 966
Author(s):  
Ji-Heng Hao ◽  
Dian-Feng Hu ◽  
Li-Mei Mao ◽  
Shi-Gang Zhang ◽  
Ji-Yue Wang ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Glioma Cells ◽  
Inhibitory Effect ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Expression Of Genes ◽  
Acid Conjugate ◽  
G0 Phase ◽  
Induced Apoptosis ◽  
Endothelial Growth Factor

<p class="Abstract">The present study was performed to investigate the effect of 2-fluorobenzaldehyde retinoic acid conjugate on activation of STAT3 pathway in human glioma cells. The results revealed that the compound exhibited inhibitory effect on the activation of STAT3 induced constitutively and by interleukin-6. The inhibitory effect on STAT3 activation was found to be concentration- and time-dependent. In U373 glioma cells, 2-fluorobenzaldehyde retinoic acid conjugate treatment caused a significant enhancement in the expression of proapoptotic proteins like Bax and Bak. Its treatment inhibited the expression of genes including, cyclin D1, Bcl-2, Bcl-xL, survivin, Mcl-1, and vascular endothelial growth factor (VEGF) in U373 glioma cells. Furthermore, the conjugate inhibited proliferation, induced apoptosis and caused accumulation of cells in G1-G0 phase of cell cycle. Thus, 2-fluorobenzaldehyde retinoic acid conjugate acts as a potent inhibitor of STAT3 activation that can be promising importance for the prevention and treatment of gliomas.</p><p> </p>

scholarly journals Mig-2 attenuates cisplatin-induced apoptosis of human glioma cells in vitro through AKT/JNK and AKT/p38 signaling pathways

2014 ◽  
Vol 35 (9) ◽  
pp. 1199-1206 ◽  
Author(s):  
Yun-wei Ou ◽  
Zi-tong Zhao ◽  
Chuan-yue Wu ◽  
Bai-nan Xu ◽  
Yong-mei Song ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Induced Apoptosis

scholarly journals Sensitization to CD95 ligand-induced apoptosis in human glioma cells by hyperthermia involves enhanced cytochrome c release

Oncogene ◽  
2000 ◽  
Vol 19 (19) ◽  
pp. 2338-2345 ◽  
Author(s):  
Mirjam Hermisson ◽  
Bettina Wagenknecht ◽  
Hartwig Wolburg ◽  
Tamara Glaser ◽  
Johannes Dichgans ◽  
...  
Keyword(s):  
Cytochrome C ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Cytochrome C Release ◽  
Cd95 Ligand ◽  
Induced Apoptosis

scholarly journals Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis

FEBS Letters ◽  
2010 ◽  
Vol 584 (16) ◽  
pp. 3519-3524 ◽  
Author(s):  
Ting-Kuang Niu ◽  
Yan Cheng ◽  
Xingcong Ren ◽  
Jin-Ming Yang
Keyword(s):  
Glioma Cells ◽  
Beclin 1 ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Induced Apoptosis

Two Different Mechanisms of Apoptosis Resistance Observed in Interferon-  Induced Apoptosis of Human Glioma Cells

2004 ◽  
Vol 67 (3) ◽  
pp. 273-280 ◽  
Author(s):  
Ryuta Saito ◽  
Masaaki Mizuno ◽  
Manabu Hatano ◽  
Toshihiro Kumabe ◽  
Takashi Yoshimoto ◽  
...  
Keyword(s):  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Apoptosis Resistance ◽  
Induced Apoptosis

scholarly journals Depressive Effectiveness of Vigabatrin (y-Vinyl-GABA), an Antiepileptic Drug, in Intermediate-conductance Calcium-Activated Potassium Channels in Human Glioma Cells

2021 ◽  
Author(s):  
Te-Yu Hung ◽  
Huai-Ying Ingrid Huang ◽  
Sheng-Nan Wu ◽  
Chin-Wei Huang
Keyword(s):  
Antiepileptic Drug ◽  
Glioma Cells ◽  
Ionic Currents ◽  
Ionic Channels ◽  
Underlying Mechanism ◽  
Inhibitory Effect ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Calcium Activated Potassium Channels ◽  
Inwardly Rectifying

Abstract Background: Vigabatrin (VGB) is an approved non-traditional antiepileptic drug that has been revealed to have potential for treating brain tumors; however, its effect on ionic channels in glioma cells remains largely unclear. Methods: With the aid of patch-clamp technology, we investigated the effects of VGB on various ionic currents in the glioblastoma multiforme cell line 13-06-MG. Results: In cell-attached configuration, VGB concentration-dependently reduced the activity of intermediate-conductance Ca2+-activated K+ (IKCa) channels, while DCEBIO (5,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one) counteracted the VGB-induced inhibition of IKCa channels. However, the activity of neither large-conductance Ca2+-activated (BKCa) nor inwardly rectifying K+ (KIR) channels were affected by the presence of VGB in human 13-06-MG cells. However, in the continued presence of VGB, the addition of GAL-021 or BaCl2 effectively suppressed BKCa and KIR channels. Conclusions: The inhibitory effect of VGB on IKCa channels demonstrated in the current study could be an important underlying mechanism of VGB-induced antineoplastic (e.g., anti-glioma) actions.

scholarly journals Migfilin sensitizes cisplatin-induced apoptosis in human glioma cells in vitro

2012 ◽  
Vol 33 (10) ◽  
pp. 1301-1310 ◽  
Author(s):  
Jing Fan ◽  
Yun-wei Ou ◽  
Chuan-yue Wu ◽  
Chun-jiang Yu ◽  
Yong-mei Song ◽  
...  
Keyword(s):  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Induced Apoptosis
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