scholarly journals Dose Response Study of a Novel Gold-Manganese Oxide Nano-Composite in an In Vivo Murine Model

2017 ◽  
Keyword(s):  
Manganese Oxide ◽  
Dose Response ◽  
Murine Model ◽  
Nano Composite ◽  
Dose Response Study

scholarly journals Activities of Several Novel Oxazolidinones againstMycobacterium tuberculosis in a Murine Model

1999 ◽  
Vol 43 (5) ◽  
pp. 1189-1191 ◽  
Author(s):  
M. H. Cynamon ◽  
S. P. Klemens ◽  
C. A. Sharpe ◽  
S. Chase
Keyword(s):  
Body Weight ◽  
Mycobacterium Tuberculosis ◽  
Dose Response ◽  
Murine Model ◽  
Clinical Studies ◽  
Viable Cell ◽  
Test System ◽  
Cell Counts ◽  
Dose Response Study

ABSTRACT The activities of linezolid, eperezolid, and PNU-100480 were evaluated in a murine model of tuberculosis. Approximately 107 viable Mycobacterium tuberculosis ATCC 35801 organisms were given intravenously to 4-week-old outbred CD-1 mice. In the first study, treatment was started 1 day postinfection and was given by gavage for 4 weeks. Viable cell counts were determined from homogenates of spleens and lungs. PNU-100480 was as active as isoniazid. Linezolid was somewhat less active than PNU-100480 and isoniazid. Eperezolid had little activity in this model. In the next two studies, treatment was started 1 week postinfection. A dose-response study was performed with PNU-100480 and linezolid (both at 25, 50, and 100 mg/kg of body weight). PNU-100480 was more active than linezolid, and its efficacy increased with an escalation of the dose. Subsequently, the activity of PNU-100480 alone and in combination with rifampin or isoniazid was evaluated and was compared to that of isoniazid-rifampin. The activity of PNU-100480 was similar to that of isoniazid and/or rifampin in the various combinations tested. Further evaluation of these oxazolidinones in the murine test system would be useful prior to the development of clinical studies with humans.

Fullerenol C 60 (OH) 36 at relatively high concentrations impairs hippocampal theta oscillations (in vivo and in vitro) and triggers epilepsy (in vitro) – A dose response study

2018 ◽  
Vol 105 (1) ◽  
pp. 98-109 ◽  
Author(s):  
Paulina Kazmierska-Grebowska ◽  
Anna Kobrzycka ◽  
Renata Bocian ◽  
Tomasz Kowalczyk ◽  
Anita Krokosz ◽  
...  
Keyword(s):  
Dose Response ◽  
Theta Oscillations ◽  
High Concentrations ◽  
Hippocampal Theta ◽  
Dose Response Study

An in vivo dose-response study of fenbendazole against Oesophagostomum dentatum and Oesophagostomum quadrispinulatum in pigs

1997 ◽  
Vol 27 (4) ◽  
pp. 403-409 ◽  
Author(s):  
J. Praslička ◽  
H. Bjørn ◽  
M. Várady ◽  
P. Nansen ◽  
D.R. Hennessy ◽  
...  
Keyword(s):  
Dose Response ◽  
Oesophagostomum Dentatum ◽  
Dose Response Study

In vivo imaging reveals prostate pathology in the PTEN knockout murine model of prostate cancer

2016 ◽  
Author(s):  
Alysha Bhatti ◽  
Almeida Gilberto Serrano de ◽  
Serena Tommasini Ghelfi ◽  
Alwyn Dart ◽  
Anabel Varela-Carver ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Murine Model ◽  
In Vivo Imaging

255-LB: Impaired Gsa/cAMP Signaling Exclusive to Pancreatic ß-Cells Exhibits a Unique Urinary Metabolome via Nontargeted Metabolomics in a Murine Model of Diabetes In Vivo

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 255-LB
Author(s):  
AMRO ILAIWY ◽  
MEGAN CAPOZZI ◽  
JENNIFER L. BROWN ◽  
DAVID D’ALESSIO ◽  
JONATHAN CAMPBELL
Keyword(s):  
Murine Model ◽  
Camp Signaling

Reduction of insulin clearance during hyperglycemic clamp. Dose-response study in normal humans

Diabetes ◽  
1988 ◽  
Vol 37 (10) ◽  
pp. 1351-1357 ◽  
Author(s):  
H. Tillil ◽  
E. T. Shapiro ◽  
A. H. Rubenstein ◽  
J. A. Galloway ◽  
K. S. Polonsky
Keyword(s):  
Dose Response ◽  
Insulin Clearance ◽  
Hyperglycemic Clamp ◽  
Normal Humans ◽  
Dose Response Study
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