THE USE OF ACTH AND CORTISONE IN IDIOPATHIC THROMBOCYTOPENIC PURPURA AND IDIOPATHIC ACQUIRED HEMOLYTIC ANEMIA

1952 ◽  
Vol 37 (2) ◽  
pp. 352 ◽  
Keyword(s):  
Hemolytic Anemia ◽  
Idiopathic Thrombocytopenic Purpura ◽  
Thrombocytopenic Purpura

scholarly journals A Case of Pregnancy Complicated with Evans Syndrome with Sequential Development of Autoimmune Warm Antibody Hemolytic Anemia and Idiopathic Thrombocytopenic Purpura

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Haruka Suzuki ◽  
Koji Yamanoi ◽  
Jumpei Ogura ◽  
Takahiro Hirayama ◽  
Koji Yasumoto ◽  
...  
Keyword(s):  
Hemolytic Anemia ◽  
Idiopathic Thrombocytopenic Purpura ◽  
Macrocytic Anemia ◽  
Evans Syndrome ◽  
Thrombocytopenic Purpura ◽  
Sequential Development ◽  
Healthy Female ◽  
Long Term Follow Up ◽  
Haptoglobin Level

The simultaneous or sequential development of autoimmune hemolytic anemia (AIHA) and idiopathic thrombocytopenic purpura (ITP) is known as Evans syndrome. We experienced a case of Evans syndrome that developed AIHA during pregnancy and ITP long after delivery. The patient was a 35-year-old pregnant woman (gravida 2, para 1). A routine blood test at 28 weeks of gestation revealed moderate macrocytic anemia. Her haptoglobin level was markedly low, and a direct antiglobulin test (DAT) was positive. Based on these results, AIHA was considered. A healthy female newborn with bodyweight 3575 g was vaginally delivered uneventfully. After delivery, the DAT remained positive, but anemia did not develop. At 203 days after delivery, ITP was detected. Because AIHA and ITP developed sequentially, she was diagnosed with Evans syndrome. When AIHA occurs during pregnancy, long-term follow-up is needed because ITP can develop sequentially.

scholarly journals Life-threatening autoimmune hemolytic anemia and idiopathic thrombocytopenic purpura: successful seletive splenic artery embolization

2016 ◽  
Vol 8 ◽  
pp. 2016020 ◽  
Author(s):  
Matteo Molica ◽  
Fulvio Massaro ◽  
Giorgia Annechini ◽  
Erminia Baldacci ◽  
Gianna maria D'elia ◽  
...  
Keyword(s):  
Hemolytic Anemia ◽  
Idiopathic Thrombocytopenic Purpura ◽  
Splenic Artery ◽  
Critical Conditions ◽  
Splenic Trauma ◽  
Artery Embolization ◽  
Splenic Artery Embolization ◽  
Thrombocytopenic Purpura ◽  
Transcatheter Occlusion ◽  
Immune Hemolytic Anemia

Selective splenic artery embolization (SSAE) is a nonsurgical intervention characterized by the transcatheter occlusion of the splenic artery and/or its branch vessels using metallic coils or other embolic devices. It has been applied for the management of splenic trauma, hypersplenism with portal hypertension, hereditary spherocytosis, thalassemia and splenic hemangioma. We hereby describe a case of a patient affected by idiopathic thrombocytopenic purpura (ITP) and warm auto-immune hemolytic anemia (AIHA) both resistant to immunosuppressive and biological therapies, not eligible for a surgical intervention because of her critical conditions. She underwent SSAE and achieved a hematologic complete response within a few days without complications. SSAE is a minimally invasive procedure to date not considered a standard option in the management of AIHA and ITP. However, following the progressive improvement of the techniques, its indications have been extended, with a reduction in morbidity and mortality compared to splenectomy in patients with critical clinical conditions. SSAE was a lifesaving therapeutic approach for our patient and it may represent a real alternative for the treatment of resistant AIHA and ITP patients not eligible for splenectomy.

scholarly journals The Use of Thorium Dioxide Sol (Thorotrast) in the Roentgenologic Demonstration of Accessory Spleens

Blood ◽  
1952 ◽  
Vol 7 (9) ◽  
pp. 904-914 ◽  
Author(s):  
VIRGIL LOEB ◽  
WILLIAM B. SEAMAN ◽  
CARL V. MOORE
Keyword(s):  
Hemolytic Anemia ◽  
Idiopathic Thrombocytopenic Purpura ◽  
Clinical Management ◽  
Hereditary Spherocytosis ◽  
Case Reports ◽  
Accessory Spleen ◽  
Illustrative Case ◽  
Thrombocytopenic Purpura ◽  
Thorium Dioxide ◽  
Accessory Spleens

Abstract Experience with the use of thorium dioxide sol (Thorotrast) in the roentgen demonstration of accessory spleens is described. The importance of the application of this technic to the clinical management of patients with hematologic relapse following splenectomy is emphasized and illustrative case reports are presented. Nine patients were given thorium dioxide in an attempt to demonstrate an accessory spleen. A remission was induced in 1 patient with acquired hemolytic anemia, who had failed to respond to splenectomy, by removal of an accessory spleen demonstrated with thorium dioxide. A second patient with hereditary spherocytosis who relapsed seven years after splenectomy was shown to have an accessory spleen. Seven patients with idiopathic thrombocytopenic purpura who had relapsed following splenectomy were given thorium dioxide and in no case was an accessory spleen found.

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