Serious Infections in Adults Exposed to Children with Haemophilus influenzae Type b Meningitis

1981 ◽  
Vol 94 (6) ◽  
pp. 785 ◽  
Author(s):  
JOSEPH F. PLOUFFE
PEDIATRICS ◽  
1983 ◽  
Vol 71 (2) ◽  
pp. 187-191
Author(s):  
Sheldon L. Kaplan ◽  
Edward O. Mason ◽  
Sally J. Kvernland ◽  
Elaine M. Loiselle ◽  
Ralph D. Feigin

Thirty-eight children completed therapy with moxalactam for a variety of non-CNS infections. Haemophilus influenzae type b (seven ampicillin-resistant strains) was the etiologic agent for 32 children. Doses of moxalactam ranged from 113 to 200 mg/kg/d in three or four divided doses administered parenterally. All children with infections due to H influenzae type b had excellent responses to moxalactam therapy. Children treated for infections due to other agents also responded satisfactorily to moxalactam therapy. Moxalactam concentrations in joint and pleural fluids greatly exceeded the minimal bactericidal concentrations of moxalactam for H influenzae type b. Adverse reactions included neutropenia, eosinophilia, thrombocytosis, and transient elevation of transaminase levels. Moxalactam administered parenterally, at a dose of 113 to 150 mg/kg/d in three or four divided doses is effective therapy for serious infections in children due to H influenzae type b and selected other organisms.


PEDIATRICS ◽  
1986 ◽  
Vol 77 (2) ◽  
pp. 242-245
Author(s):  
JANET R. GILSDORF

Haemophilus influenzae type b, a major cause of serious infections in infants and young children, may colonize the nasopharynges of healthy, asymptomatic carriers as well as patients with invasive H influenzae type b disease. Person to person spread of this organism is suspected to be by infected respiratory tract secretions. Recently, clusters of epidemiologically related cases have been recognized among young household and day-care contacts of children with H influenzae type b disease,1 demonstrating the contagious potential of H influenzae type b infections. Serious nosocomial infections with H influenzae type b have been described in pediatric patients in acute and chronic care hospitals.2-4


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