scholarly journals Anatomical and functional organization of the human substantia nigra and its connections

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Yu Zhang ◽  
Kevin Michel-Herve Larcher ◽  
Bratislav Misic ◽  
Alain Dagher
Keyword(s):  
Substantia Nigra ◽  
Functional Organization ◽  
Impulsive Choice ◽  
Behavioral Measures ◽  
Human Connectome Project ◽  
Motor Impulsivity ◽  
Cortical Regions ◽  
Value Coding ◽  
Decisional Impulsivity ◽  
Human Substantia Nigra

We investigated the anatomical and functional organization of the human substantia nigra (SN) using diffusion and functional MRI data from the Human Connectome Project. We identified a tripartite connectivity-based parcellation of SN with a limbic, cognitive, motor arrangement. The medial SN connects with limbic striatal and cortical regions and encodes value (greater response to monetary wins than losses during fMRI), while the ventral SN connects with associative regions of cortex and striatum and encodes salience (equal response to wins and losses). The lateral SN connects with somatomotor regions of striatum and cortex and also encodes salience. Behavioral measures from delay discounting and flanker tasks supported a role for the value-coding medial SN network in decisional impulsivity, while the salience-coding ventral SN network was associated with motor impulsivity. In sum, there is anatomical and functional heterogeneity of human SN, which underpins value versus salience coding, and impulsive choice versus impulsive action.

scholarly journals Anatomical and functional organization of the human substantia nigra and its connections

2017 ◽  
Author(s):  
Yu Zhang ◽  
Kevin Larcher ◽  
Bratislav Misic ◽  
Alain Dagher
Keyword(s):  
Substantia Nigra ◽  
Functional Organization ◽  
Impulsive Choice ◽  
Functional Heterogeneity ◽  
Human Connectome Project ◽  
Motor Impulsivity ◽  
Cortical Regions ◽  
Value Coding ◽  
Decisional Impulsivity ◽  
Human Substantia Nigra

AbstractWe investigated the anatomical and functional organization of the human substantia nigra (SN) using diffusion and functional MRI data from the Human Connectome Project. We identified a tripartite connectivity-based parcellation of SN with a limbic, cognitive and motor arrangement. The medial SN connects with limbic striatal and cortical regions and encodes value (greater response to monetary wins than losses during fMRI), while the ventral SN connects with associative regions of cortex and striatum and encodes salience (equal response to wins and losses). The lateral SN connects with somatomotor regions of striatum and cortex and also encodes salience. Connectivity within the value-coding medial SN network was associated with a measure of decisional impulsivity, while the salience-coding ventral SN network was associated with motor impulsivity. In sum, there is anatomical and functional heterogeneity of human SN, and separate SN networks underpin value versus salience coding, and impulsive choice versus impulsive action.

scholarly journals Author response: Anatomical and functional organization of the human substantia nigra and its connections

2017 ◽  
Author(s):  
Yu Zhang ◽  
Kevin Michel-Herve Larcher ◽  
Bratislav Misic ◽  
Alain Dagher
Keyword(s):  
Substantia Nigra ◽  
Functional Organization ◽  
Author Response ◽  
Human Substantia Nigra

Marked microglial reaction in normal aging human substantia nigra: correlation with extraneuronal neuromelanin pigment deposits

2007 ◽  
Vol 114 (4) ◽  
pp. 419-424 ◽  
Author(s):  
Thomas G. Beach ◽  
Lucia I. Sue ◽  
Douglas G. Walker ◽  
Lih Fen Lue ◽  
Donald J. Connor ◽  
...  
Keyword(s):  
Substantia Nigra ◽  
Normal Aging ◽  
Human Substantia Nigra

Nucleolin in Neurons of the Human Substantia Nigra

2018 ◽  
Vol 12 (2) ◽  
pp. 205-208
Author(s):  
D. A. Sufieva ◽  
V. V. Guselnikova ◽  
D. E. Korzhevskii
Keyword(s):  
Substantia Nigra ◽  
Human Substantia Nigra

scholarly journals Hippocampal Contributions to Episodic Encoding: Insights From Relational and Item-Based Learning

2002 ◽  
Vol 88 (2) ◽  
pp. 982-990 ◽  
Author(s):  
Lila Davachi ◽  
Anthony D. Wagner
Keyword(s):  
Working Memory ◽  
Medial Temporal Lobe ◽  
Memory Formation ◽  
Relational Processing ◽  
Behavioral Measures ◽  
Fmri Study ◽  
Episodic Encoding ◽  
Hippocampus Proper ◽  
Temporal Structures ◽  
Cortical Regions

The integrity of the hippocampus and surrounding medial-temporal cortices is critical for episodic memory, with the hippocampus being posited to support relational or configural associative learning. The present event-related functional magnetic resonance imaging (fMRI) study investigated the role of specific medial-temporal lobe structures in learning during relational and item-based processing, as well as the extent to which these structures are engaged during item-based maintenance of stimuli in working memory. fMRI indexed involvement of the hippocampus and underlying cortical regions during performance of two verbal encoding conditions, one that required item-based maintenance of word triplets in working memory and the other that entailed the formation of inter-item associations across the words in each triplet. Sixteen subjects were scanned using a rapid event-related fMRI design while they encountered the item-based and relational processing trials. To examine the correlation between fMRI signal in medial-temporal structures during learning and the subject's subsequent ability to remember the stimuli (a measure of effective memory formation), subjects were administered a yes-no recognition memory test following completion of the encoding scans. Results revealed that the hippocampus proper was engaged during both relational and item-based processing, with relational processing resulting in a greater hippocampal response. By contrast, entorhinal and parahippocampal gyri were differentially engaged during item-based processing, providing strong evidence for a functional neuroanatomic distinction between hippocampal and parahippocampal structures. Analysis of the neural correlates of subsequent memory revealed that activation in the bilateral hippocampus was reliably correlated with behavioral measures of effective memory formation only for those stimuli that were encoded in a relational manner. Taken together, these data provide evidence that the hippocampus, while engaged during item-based working memory maintenance, differentially subserves the relational binding of items into an integrated memory trace so that the experience can be later remembered.

Distribution of [3H]SCH 23390 Binding Sites in the Human Substantia Nigra

1991 ◽  
pp. 93-94
Author(s):  
F. Thibaut ◽  
E.C. Hirsch ◽  
R. Raisman ◽  
F. Javoy-Agid ◽  
Y. Agid
Keyword(s):  
Substantia Nigra ◽  
Binding Sites ◽  
Sch 23390 ◽  
Human Substantia Nigra

scholarly journals Quantitative Profiling of the Human Substantia Nigra Proteome from Laser-capture Microdissected FFPE Tissue

2020 ◽  
Vol 19 (5) ◽  
pp. 839-851 ◽  
Author(s):  
Eva Griesser ◽  
Hannah Wyatt ◽  
Sara Ten Have ◽  
Birgit Stierstorfer ◽  
Martin Lenter ◽  
...  
Keyword(s):  
Substantia Nigra ◽  
Solid Phase ◽  
Neuronal Cell ◽  
Alpha Synuclein ◽  
Ffpe Tissue ◽  
Specific Gene ◽  
Tissue Specimens ◽  
Laser Capture ◽  
Go Terms ◽  
Human Substantia Nigra

Laser-capture microdissection (LCM) allows the visualization and isolation of morphologically distinct subpopulations of cells from heterogeneous tissue specimens. In combination with formalin-fixed and paraffin-embedded (FFPE) tissue it provides a powerful tool for retrospective and clinically relevant studies of tissue proteins in a healthy and diseased context. We first optimized the protocol for efficient LCM analysis of FFPE tissue specimens. The use of SDS containing extraction buffer in combination with the single-pot solid-phase-enhanced sample preparation (SP3) digest method gave the best results regarding protein yield and protein/peptide identifications. Microdissected FFPE human substantia nigra tissue samples (∼3,000 cells) were then analyzed, using tandem mass tag (TMT) labeling and LC-MS/MS, resulting in the quantification of >5,600 protein groups. Nigral proteins were classified and analyzed by abundance, showing an enrichment of extracellular exosome and neuron-specific gene ontology (GO) terms among the higher abundance proteins. Comparison of microdissected samples with intact tissue sections, using a label-free shotgun approach, revealed an enrichment of neuronal cell type markers, such as tyrosine hydroxylase and alpha-synuclein, as well as proteins annotated with neuron-specific GO terms. Overall, this study provides a detailed protocol for laser-capture proteomics using FFPE tissue and demonstrates the efficiency of LCM analysis of distinct cell subpopulations for proteomic analysis using low sample amounts.

scholarly journals Frequency-dependent circuits anchored in the dorsal and ventral left anterior insula

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yifeng Wang ◽  
Qijun Zou ◽  
Yujia Ao ◽  
Yang Liu ◽  
Yujie Ouyang ◽  
...  
Keyword(s):  
Functional Organization ◽  
Functional Integration ◽  
Anterior Insula ◽  
Frequency Effect ◽  
Frequency Dependent ◽  
Functional Connections ◽  
Human Connectome Project ◽  
Cognitive Neurosciences ◽  
The Right

Abstract The hub role of the right anterior insula (AI) has been emphasized in cognitive neurosciences and been demonstrated to be frequency-dependently organized. However, the functional organization of left AI (LAI) has not been systematically investigated. Here we used 100 unrelated datasets from the Human Connectome Project to study the frequency-dependent organization of LAI along slow 6 to slow 1 bands. The broadband functional connectivity of LAI was similar to previous findings. In slow 6-slow 3 bands, both dorsal and ventral seeds in LAI were correlated to the salience network (SN) and language network (LN) and anti-correlated to the default mode network (DMN). However, these seeds were only correlated to the LAI in slow 2-slow 1 bands. These findings indicate that broadband and narrow band functional connections reflect different functional organizations of the LAI. Furthermore, the dorsal seed had a stronger connection with the LN and anti-correlation with DMN while the ventral seed had a stronger connection within the SN in slow 6-slow 3 bands. In slow 2-slow 1 bands, both seeds had stronger connections with themselves. These observations indicate distinctive functional organizations for the two parts of LAI. Significant frequency effect and frequency by seed interaction were also found, suggesting different frequency characteristics of these two seeds. The functional integration and functional segregation of LDAI and LVAI were further supported by their cognitive associations. The frequency- and seed-dependent functional organizations of LAI may enlighten future clinical and cognitive investigations.

scholarly journals Novelty-Sensitive Dopaminergic Neurons in the Human Substantia Nigra Predict Success of Declarative Memory Formation

2018 ◽  
Vol 28 (9) ◽  
pp. 1333-1343.e4 ◽  
Author(s):  
Jan Kamiński ◽  
Adam N. Mamelak ◽  
Kurtis Birch ◽  
Clayton P. Mosher ◽  
Michele Tagliati ◽  
...  
Keyword(s):  
Substantia Nigra ◽  
Dopaminergic Neurons ◽  
Declarative Memory ◽  
Memory Formation ◽  
Human Substantia Nigra
Sign in / Sign up

Export Citation Format

Share Document