scholarly journals Decision letter: Microglial depletion disrupts normal functional development of adult-born neurons in the olfactory bulb

2019 ◽  
Author(s):  
Amanda Sierra
Keyword(s):  
Olfactory Bulb ◽  
Functional Development ◽  
Normal Functional ◽  
Adult Born Neurons

scholarly journals Microglial depletion disrupts normal functional development of adult-born neurons in the olfactory bulb

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Jenelle Wallace ◽  
Julia Lord ◽  
Lasse Dissing-Olesen ◽  
Beth Stevens ◽  
Venkatesh N Murthy
Keyword(s):  
Olfactory Bulb ◽  
Adult Mouse ◽  
Granule Cells ◽  
Excitatory Synapses ◽  
Adult Mouse Brain ◽  
Functional Development ◽  
Normal Functional ◽  
Adult Born Neurons ◽  
Mushroom Spines

Microglia play key roles in regulating synapse development and refinement in the developing brain, but it is unknown whether they are similarly involved during adult neurogenesis. By transiently depleting microglia from the healthy adult mouse brain, we show that microglia are necessary for the normal functional development of adult-born granule cells (abGCs) in the olfactory bulb. Microglial depletion reduces the odor responses of developing, but not preexisting GCs in vivo in both awake and anesthetized mice. Microglia preferentially target their motile processes to interact with mushroom spines on abGCs, and when microglia are absent, abGCs develop smaller spines and receive weaker excitatory synaptic inputs. These results suggest that microglia promote the development of excitatory synapses onto developing abGCs, which may impact the function of these cells in the olfactory circuit.

scholarly journals Microglia depletion disrupts normal functional development of adult-born neurons in the olfactory bulb

2019 ◽  
Author(s):  
Jenelle Wallace ◽  
Julia Lord ◽  
Lasse Dissing-Olesen ◽  
Beth Stevens ◽  
Venkatesh Murthy
Keyword(s):  
Olfactory Bulb ◽  
Adult Mouse ◽  
Granule Cells ◽  
Excitatory Synapses ◽  
Adult Mouse Brain ◽  
Functional Development ◽  
Normal Functional ◽  
Adult Born Neurons ◽  
Mushroom Spines

AbstractMicroglia play key roles in regulating synapse development and refinement in the developing brain, but it is unknown whether they are similarly involved during adult neurogenesis. By transiently ablating microglia from the healthy adult mouse brain, we show that microglia are necessary for the normal functional development of adult-born granule cells (abGCs) in the olfactory bulb. Microglia ablation reduces the odor responses of developing, but not preexisting GCs in vivo in both awake and anesthetized mice. Microglia preferentially target their motile processes to interact with mushroom spines on abGCs, and when microglia are absent, abGCs develop smaller spines and receive weaker excitatory synaptic inputs. These results suggest that microglia promote the development of excitatory synapses onto developing abGCs, which may impact the function of these cells in the olfactory circuit.

scholarly journals Author response: Microglial depletion disrupts normal functional development of adult-born neurons in the olfactory bulb

2019 ◽  
Author(s):  
Jenelle Wallace ◽  
Julia Lord ◽  
Lasse Dissing-Olesen ◽  
Beth Stevens ◽  
Venkatesh N Murthy
Keyword(s):  
Olfactory Bulb ◽  
Author Response ◽  
Functional Development ◽  
Normal Functional ◽  
Adult Born Neurons

scholarly journals Adult-born neurons facilitate olfactory bulb pattern separation during task engagement

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Wankun L Li ◽  
Monica W Chu ◽  
An Wu ◽  
Yusuke Suzuki ◽  
Itaru Imayoshi ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Adult Neurogenesis ◽  
Task Engagement ◽  
Pattern Separation ◽  
Inhibitory Neurons ◽  
Dependent Manner ◽  
Genetic Method ◽  
Two Photon ◽  
Passive Exposure ◽  
Adult Born Neurons

The rodent olfactory bulb incorporates thousands of newly generated inhibitory neurons daily throughout adulthood, but the role of adult neurogenesis in olfactory processing is not fully understood. Here we adopted a genetic method to inducibly suppress adult neurogenesis and investigated its effect on behavior and bulbar activity. Mice without young adult-born neurons (ABNs) showed normal ability in discriminating very different odorants but were impaired in fine discrimination. Furthermore, two-photon calcium imaging of mitral cells (MCs) revealed that the ensemble odor representations of similar odorants were more ambiguous in the ablation animals. This increased ambiguity was primarily due to a decrease in MC suppressive responses. Intriguingly, these deficits in MC encoding were only observed during task engagement but not passive exposure. Our results indicate that young olfactory ABNs are essential for the enhancement of MC pattern separation in a task engagement-dependent manner, potentially functioning as a gateway for top-down modulation.

scholarly journals Functional development of the olfactory bulb and a unique glomerular complex in the neonatal rat

1982 ◽  
Vol 2 (12) ◽  
pp. 1744-1759 ◽  
Author(s):  
CA Greer ◽  
WB Stewart ◽  
MH Teicher ◽  
GM Shepherd
Keyword(s):  
Olfactory Bulb ◽  
Neonatal Rat ◽  
Functional Development

scholarly journals GluN2B-Containing NMDA Receptors Promote Wiring of Adult-Born Neurons into Olfactory Bulb Circuits

2012 ◽  
Vol 32 (36) ◽  
pp. 12603-12611 ◽  
Author(s):  
W. Kelsch ◽  
Z. Li ◽  
M. Eliava ◽  
C. Goengrich ◽  
H. Monyer
Keyword(s):  
Olfactory Bulb ◽  
Nmda Receptors ◽  
Adult Born Neurons

scholarly journals Dynamic development of the first synapse impinging on adult-born neurons in the olfactory bulb circuit

2011 ◽  
Vol 1 (1) ◽  
pp. 6 ◽  
Author(s):  
Hiroyuki Katagiri ◽  
Marta Pallotto ◽  
Antoine Nissant ◽  
Kerren Murray ◽  
Marco Sassoè-Pognetto ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Dynamic Development ◽  
Adult Born Neurons

Regulation of survival and death of adult-born neurons in the local area of the olfactory bulb by local sensory input

2010 ◽  
Vol 68 ◽  
pp. e368
Author(s):  
Daisuke Mochimaru ◽  
Ko Kobayakawa ◽  
Reiko Kobayakawa ◽  
Hitoshi Sakano ◽  
Kensaku Mori ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Sensory Input ◽  
Local Area ◽  
Adult Born Neurons

scholarly journals The Role of Adult-Born Neurons in the Constantly Changing Olfactory Bulb Network

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Sarah Malvaut ◽  
Armen Saghatelyan
Keyword(s):  
Olfactory Bulb ◽  
Synapse Formation ◽  
Daily Basis ◽  
Mammalian Brain ◽  
Neuronal Progenitors ◽  
Neuronal Precursors ◽  
Continuous Progress ◽  
Adult Born Neurons ◽  
Migratory Stream

The adult mammalian brain is remarkably plastic and constantly undergoes structurofunctional modifications in response to environmental stimuli. In many regions plasticity is manifested by modifications in the efficacy of existing synaptic connections or synapse formation and elimination. In a few regions, however, plasticity is brought by the addition of new neurons that integrate into established neuronal networks. This type of neuronal plasticity is particularly prominent in the olfactory bulb (OB) where thousands of neuronal progenitors are produced on a daily basis in the subventricular zone (SVZ) and migrate along the rostral migratory stream (RMS) towards the OB. In the OB, these neuronal precursors differentiate into local interneurons, mature, and functionally integrate into the bulbar network by establishing output synapses with principal neurons. Despite continuous progress, it is still not well understood how normal functioning of the OB is preserved in the constantly remodelling bulbar network and what role adult-born neurons play in odor behaviour. In this review we will discuss different levels of morphofunctional plasticity effected by adult-born neurons and their functional role in the adult OB and also highlight the possibility that different subpopulations of adult-born cells may fulfill distinct functions in the OB neuronal network and odor behaviour.

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