Microbiome Research in Atopic Dermatitis

The prevalence of allergic disorders has been increasing worldwide and significantly impacts the quality of life of the atopic individual. There has been an increased interest in the role of probiotics for the prevention and treatment of allergic disorders, given the recent evidence that atopy risk may be associated with a dysbiosis of the gut microbiome. Research in this area is ongoing with some studies showing possible benefits of probiotics, with seemingly little to no risk. While these studies suggest that there may be a promise in probiotic use for the prevention or treatment of allergy, further evidence is needed to determine its efficacy, optimal dosing, and strains needed for treatment. In this review, we discuss recently published studies examining the benefits, risks, and role of probiotics in preventing atopic dermatitis, asthma, allergic rhinitis, and food allergy.

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Microbiome research in food allergy and atopic dermatitis

Allergy Asthma & Respiratory Disease ◽

10.4168/aard.2016.4.6.389 ◽

2016 ◽

Vol 4 (6) ◽

pp. 389 ◽

Cited By ~ 4

Author(s):

Min-Hye Kim ◽

Dong In Suh ◽

Soo-Young Lee ◽

Yoon-Keun Kim ◽

Young-Joo Cho ◽

...

Keyword(s):

Atopic Dermatitis ◽

Food Allergy ◽

Microbiome Research

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Combining integrated systems-biology approaches with intervention-based experimental design provides a higher-resolution path forward for microbiome research

Behavioral and Brain Sciences ◽

10.1017/s0140525x18002911 ◽

2019 ◽

Vol 42 ◽

Author(s):

J. Alfredo Blakeley-Ruiz ◽

Carlee S. McClintock ◽

Ralph Lydic ◽

Helen A. Baghdoyan ◽

James J. Choo ◽

...

Keyword(s):

Systems Biology ◽

High Resolution ◽

Experimental Design ◽

Integrated Systems ◽

Microbiome Research ◽

Constructive Criticism

Abstract The Hooks et al. review of microbiota-gut-brain (MGB) literature provides a constructive criticism of the general approaches encompassing MGB research. This commentary extends their review by: (a) highlighting capabilities of advanced systems-biology “-omics” techniques for microbiome research and (b) recommending that combining these high-resolution techniques with intervention-based experimental design may be the path forward for future MGB research.

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Inter-individual variation shapes the human microbiome

Behavioral and Brain Sciences ◽

10.1017/s0140525x1800287x ◽

2019 ◽

Vol 42 ◽

Author(s):

Emily F. Wissel ◽

Leigh K. Smith

Keyword(s):

Individual Differences ◽

Individual Variation ◽

Human Microbiome ◽

Individual Variability ◽

Microbiota Composition ◽

Target Article ◽

Microbiome Research

Abstract The target article suggests inter-individual variability is a weakness of microbiota-gut-brain (MGB) research, but we discuss why it is actually a strength. We comment on how accounting for individual differences can help researchers systematically understand the observed variance in microbiota composition, interpret null findings, and potentially improve the efficacy of therapeutic treatments in future clinical microbiome research.

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