The Role of Probiotics in Preventing Allergic Disease

The prevalence of allergic disorders has been increasing worldwide and significantly impacts the quality of life of the atopic individual. There has been an increased interest in the role of probiotics for the prevention and treatment of allergic disorders, given the recent evidence that atopy risk may be associated with a dysbiosis of the gut microbiome. Research in this area is ongoing with some studies showing possible benefits of probiotics, with seemingly little to no risk. While these studies suggest that there may be a promise in probiotic use for the prevention or treatment of allergy, further evidence is needed to determine its efficacy, optimal dosing, and strains needed for treatment. In this review, we discuss recently published studies examining the benefits, risks, and role of probiotics in preventing atopic dermatitis, asthma, allergic rhinitis, and food allergy.

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Role of innate lymphoid cells in allergic diseases

Allergy and Asthma Proceedings ◽

10.2500/aap.2019.40.4217 ◽

2019 ◽

Vol 40 (3) ◽

pp. 138-145 ◽

Cited By ~ 14

Author(s):

M. Asghar Pasha ◽

Gargi Patel ◽

Russell Hopp ◽

Qi Yang

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Allergic Diseases ◽

Innate Lymphoid Cells ◽

Lymphoid Cells ◽

Food Allergies ◽

Antigen Receptors ◽

Medline Search ◽

Allergic Disorders

Background: Over the past decade, there has been increasing interest and research into understanding the type 2 immune responses by the epithelium-derived cytokines interleukin (IL) 33, IL-25, and thymic stromal lymphopoietin. Innate lymphoid cells (ILC) are a unique family of effector immune cells that functionally resemble T cells but lack clonal distributed antigen receptors. Group 2 ILCs, ILC2s, are known for their capability to secrete proallergic cytokines, including IL-5 and IL-13. ILC2s are enriched at mucosal barriers in lung, gut, and skin, and their activation has been associated with a variety of allergic disorders. Objective: To study the role of ILC2 in different allergic disorders, including allergic rhinitis, asthma, atopic dermatitis, and food allergies. Methods: A MEDLINE search was performed for articles that reported on ILC2 in allergic disorders, including allergic rhinitis, asthma, atopic dermatitis, and food allergies. Results: A review of the literature revealed an important role of ILC2 in various allergic disorders. Conclusion: Identification of ILC2s in patients with allergic rhinitis, asthma, and atopic dermatitis indicates that these cells may represent a new therapeutic target. In this review, we discussed the current understanding of ILC2 biology and its function and regulation in various allergic diseases.

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Neuroimmune mechanisms of pruritus in atopic dermatitis

Medical alphabet ◽

10.33667/2078-5631-2021-41-12-16 ◽

2022 ◽

pp. 12-16

Author(s):

Y. A. Kandrashkina ◽

E. A. Orlova ◽

A. A. Pribytkov

Keyword(s):

Quality Of Life ◽

Atopic Dermatitis ◽

Skin Disease ◽

Neurogenic Inflammation ◽

New Methods ◽

Neuroimmune Interactions ◽

High Prevalence ◽

Depth Study

Atopic dermatitis is a chronic hereditary recurrent skin disease. One of the most pronounced symptoms of this dermatosis is itchy skin. Pruritus accompanies atopic dermatitis in more than 80% of cases. This review presents modern data on the mechanisms of pruritus formation in atopic dermatitis. The issues of etiological factors, neuroimmune interactions, peculiarities of skin dysfunction, as well as the role of stress are considered. The relevance of studying the topic is due to the high prevalence of atopic dermatitis among the population, a decrease in the quality of life and the lack of effective therapy. Analysis of the literature indicates the need for a comprehensive assessment of the pathogenetic mechanisms of the development of pruritus in atopic dermatitis. A more in-depth study of the mechanisms of neurogenic inflammation in atopic dermatitis will contribute to the development of new methods of diagnosis and treatment.

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The role of the nurse in the care and management of patients with atopic dermatitis

BMC Nursing ◽

10.1186/s12912-020-00494-y ◽

2020 ◽

Vol 19 (1) ◽

Author(s):

Harmieke van Os-Medendorp ◽

Elfie Deprez ◽

Nele Maes ◽

Sheila Ryan ◽

Karina Jackson ◽

...

Keyword(s):

Quality Of Life ◽

Atopic Dermatitis ◽

Treatment Adherence ◽

Self Management ◽

Severe Atopic Dermatitis ◽

Main Body ◽

Wide Range

Abstract Background The purpose of this paper is to provide an overview of key aspects of specialised dermatology nursing practice in the management of patients with moderate to severe atopic dermatitis. The role of dermatology nurse specialists in supporting patients and promoting disease understanding, education and treatment adherence continues to evolve. As features of specialised nursing care can also inform other nursing staff in a wide range of care settings, an overview of key components is examined. Observations presented are from a pan-European perspective and represent the collected view of a group of dermatology nurse specialists, dermatologists and patient advocates following two round-table discussions. Main body Atopic dermatitis is a common, chronic, inflammatory disease characterised by erythematous/scaling skin lesions, with often intense pruritus. Disease course is cyclic with periodic disease flares of varying intensity, presenting management challenges to patients and families. Dermatology nurse specialists play a key role in providing education and substantial patient support to improve treatment outcomes and quality of life to patients and their family, delivered within a multidisciplinary team framework. Nurse-led education and 'eczema schools’ are of benefit in reducing disease severity and improving quality of life by enhancing self-management, adherence and patient engagement. eHealth tools, such as patient portals or online training platforms, can provide online learning, individualised education, and help to improve engagement. These and other initiatives, such as written action plans, are all essential to improve or maintain treatment adherence, self-management and quality of life. Conclusions Dermatology nurse specialists play a central role in the assessment and management of moderate to severe atopic dermatitis patients and families. This places them in an ideal position to build strong and often long-term relationships with patients and parents. Such engagement promotes trust, assists in setting realistic expectations of treatment and outcomes, and enhances self-management and engagement in their own care. Providing emotional support, as well as formal and systematic education (including individualised practical advice) all contribute to improved treatment adherence and can enhance the quality of life of patients and their families throughout the course of this long-term condition.

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Pruritus and Atopic Dermatitis: from Etiological Features to Management

Вопросы современной педиатрии ◽

10.15690/vsp.v19i6.2151 ◽

2020 ◽

Vol 19 (6) ◽

pp. 468-476

Author(s):

Nikolay N. Murashkin ◽

Leonid A. Opryatin ◽

Roman V. Epishev ◽

Alexander I. Materikin ◽

Eduard T. Ambarchian ◽

...

Keyword(s):

Quality Of Life ◽

Atopic Dermatitis ◽

Immune System ◽

Clinical Studies ◽

Clinical Manifestations ◽

Skin Barrier ◽

Current Data ◽

Scientific Images

Pruritus is one of the main clinical manifestations of atopic dermatitis, and it significantly reduces the quality of life of patients in childhood. Scientific images on its pathophysiological basis have now undergone significant changes. The histamine exceptional role in pruritus development was confounded, as well as data on immune system involvement in its maintenance was given. This article presents current data on differential approaches to pruritus management depending on its etiopathogenetic characteristics. The role of dermocosmetics in restoration of the skin barrier as the first stage prevention of pruritus in atopic dermatitis was considered. The results of clinical studies showing efficacy of topical agents (innovative component with anti-pruritic action — STIMU-TEX) application are presented.

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Allergy-Related Diseases and Risk of Breast Cancer: The Role of Skewed Immune System on This Association

Allergy & Rhinology ◽

10.1177/2152656719860820 ◽

2019 ◽

Vol 10 ◽

pp. 215265671986082 ◽

Cited By ~ 1

Author(s):

Fatemeh Sadeghi ◽

Mohammad Shirkhoda

Keyword(s):

Breast Cancer ◽

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Immune System ◽

Immunological Mechanism ◽

Prick Test ◽

Increased Risk ◽

History Of ◽

Allergic Disorders

Background The role of allergy in breast cancer (BC) development remains inconclusive. A comprehensive review article is required to present and discuss all findings on this topic and to clarify the association between allergic disorders and the risk of BC. Objective We aimed to explain the association between atopy, different types of allergic disorders, and the risk of BC. Moreover, we explored the immunological mechanism behind this association. Methods We electronically reviewed publications in PubMed from 1979 to 2018 relating to atopy, allergy, asthma, atopic dermatitis, allergic rhinitis, food allergy, drug allergy, immunoglobulin E (IgE) or prick test, and BC. Results Most of the identified studies demonstrated nonsignificant results. However, the pattern of the results indicated an increased risk of BC in individuals with a history of allergies. The majority of studies reported higher prevalence of atopic dermatitis and allergic rhinitis among individuals with BC compared to the control groups. Similarity, most of the studies revealed an increased risk of BC among people with a positive history of atopic using IgE specific or prick test. However, a null association was reported in most of the asthmatic studies, and controversial results were detected in the individuals with history of food and drug allergies. Conclusion The majority of findings were not statistically significant. Moreover, bias and other methodological problems are the major issues, which make it challenging to compare the findings of different studies and reach a strong conclusive result. However, the pattern of the results from most studies indicated that allergic diseases might be associated with an increased risk of BC. Skewed immune system toward T-helper 2 might have an important role in this association.

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THE ROLE OF MODERN ANTIHISTAMINES IN THE TREATMENT OF ALLERGIC DISEASES

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja299 ◽

2017 ◽

Vol 14 (4-5) ◽

pp. 80-88

Author(s):

N M Nenasheva

Keyword(s):

Quality Of Life ◽

Allergic Rhinitis ◽

Second Generation ◽

Allergic Diseases ◽

Pharmaceutical Market ◽

Common Diseases ◽

First Choice ◽

Antihistamine Drug

Allergic rhinitis and urticaria - are common diseases which influence on the quality of life of patients reducing day activity and educability. The second generation of antihistamines are the first choice in the treatment of these diseases. At Russian pharmaceutical market a few dozens of different preparations of this group are available. Most of them are generic forms. The purpose of this article is to show the place of modern antihistamines in allergic rhinitis and urticaria therapy and to find out the best equivalent of generic antihistamine drug in comparison with the original one.

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Hubungan kadar leptin serum dengan derajat rinitis alergi

Oto Rhino Laryngologica Indonesiana ◽

10.32637/orli.v41i1.56 ◽

2011 ◽

Vol 41 (1) ◽

pp. 30

Author(s):

Ahmad Dian Wahyudiono ◽

Endang Retnoningsih ◽

Pudji Rahaju

Keyword(s):

Quality Of Life ◽

Allergic Rhinitis ◽

Cross Sectional ◽

Serum Leptin ◽

Sensitization Process ◽

Cross Sectional Design ◽

The Relationship ◽

Global Health Problem

Background: Allergic rhinitis is a global health problem that could impair the patient’s quality of life. Recent studies had showed the role of leptin, a hormone that produced by adipose tissue, on sensitization process which can increase the serum level of B cells and IgE. Purpose: To define the relationship between serum leptin level with the degree of allergic rhinitis based on ARIA and VAS.Methods: This study involved 38 subjects with cross sectional design. Statistical analysis included t-test, logistic regression and Kruskal-Wallis. Results: This study showed serum leptin level has correlation with the degree of allergic rhinitis based on ARIA (p<0.05), specifically on the intensity of allergic rhinitis (p<0.05), but not with the degree of allergic rhinitis based on VAS. Conclusion: Serum leptin level has a role on the degree of allergic rhinitis specifically on the intensity but not on the severity of allergic rhinitis symptoms. Controlling the serum leptin level can be considered as health promotion for patient with allergic rhinitis. Further research focusing on controlling serum leptin level for allergic rhinitis symptoms is recommended. Keywords: allergic rhinitis, serum leptin level, degree of allergic rhinitis Abstrak : Latar belakang: Rinitis alergi merupakan masalah kesehatan global dan dapat mengganggu kualitas hidup penderitanya. Beberapa penelitian telah menunjukkan peran leptin, hormon yang diproduksi oleh jaringan lemak, pada proses sensitisasi yang ditandai dengan kemampuan leptin meningkatkan sel B dan IgE. Tujuan: Penelitian ini bertujuan mengetahui hubungan kadar leptin serum dengan derajat rinitis alergi. Metode: Penelitian ini melibatkan 38 subjek dengan desain potong lintang untuk mengetahui hubungan kadar leptin serum dengan derajat rinitis alergi pada penderita rinitis alergi. Analisis statistik yang digunakan adalah uji t, uji regresi dan Kruskal-Wallis.Hasil: Penelitian ini menunjukkan bahwa kadar leptin serum berhubungan dengan derajat rinitis alergi berdasarkan ARIA (p<0,05) khususnya dengan intensitas keluhannya (p<0,05), namun tidak berhubungan dengan derajat rinitis berdasarkan VAS. Kesimpulan: Kadar leptin serum berhubungan dengan derajat rinitis alergi terutama pada intensitas keluhan dan bukan pada beratnya keluhan. Pengendalian kadar leptin serum dapat dipertimbangkan sebagai upaya memperbaiki kesehatan penderita rinitis alergi. Penelitian lebih lanjut yang menekankan pada pengendalian kadar serum leptin disarankan untuk mengendalikan keluhan rinitis alergi. Kata kunci: rinitis alergi, kadar leptin serum, derajat rinitis alergi

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NEW OPPORTUNITIES OF THERAPY OF SEVERE ATOPIC DERMATITIS

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja1465 ◽

2021 ◽

Author(s):

Irina Vladimirovna Demko ◽

Elena Albertovna Sobko ◽

Angelina Yurievna Kraposhina ◽

Natalia Alekseevna Shestakova ◽

Natalia Vladimirovna Gordeeva ◽

...

Keyword(s):

Quality Of Life ◽

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Standard Therapy ◽

Biological Therapy ◽

Regional Hospital ◽

Severe Atopic Dermatitis ◽

Skin Symptoms ◽

The Russian Federation

The article presents a case of successful use of the drug Dupilumab in a 21-year-old patient with severe atopic dermatitis, concomitant bronchial asthma and allergic rhinitis. The patient was observed in the allergological department of the Krasnoyarsk Clinical Regional Hospital for 2 years. The disease was characterized by constant skin symptoms, frequent exacerbations, resistance to standard therapy, including systemic glucocorticosteroids and cytostatics. Considering the above factors, it was decided to begin targeted therapy with Dupilumab, registered in the Russian Federation for use in atopic dermatitis resistant to standard therapy. Against the background of biological therapy (13 injections were carried out), a stable significant decrease in skin syndrome activity was achieved (SCORAD index decreased from 72 to 9 points), the patient's quality of life significantly improved.

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The Microbiome and the Public’s Health

Pained ◽

10.1093/oso/9780197510384.003.0017 ◽

2020 ◽

pp. 53-56

Author(s):

Michael D. Stein ◽

Sandro Galea

Keyword(s):

Public Health ◽

Quality Of Life ◽

Social Networks ◽

Microbial Community ◽

Health Planning ◽

Scientific Field ◽

Microbiome Research ◽

Hard Problems

This chapter examines the possible role of the microbiome in public health. Every person is a living ecosystem with trillions of microorganisms living on and in their bodies—their microbiome. Microbiome research is a relatively new scientific field where everything seems to influence it; the microbiome’s composition is altered by sleep, stress, and exercise. Microbiome scientists believe it would indeed be meaningful if, someday, by controlling one’s behaviors, one might know how to control one's personal microbial community and thus one’s health. Yet a “personalized” microbiome remains a distant and unlikely dream. Microbiome scientists agree that the environment, from the personal to the atmospheric, matters. And that people’s social networks, with whom and how they interact, matter too. As such, it is important to prioritize attention to the known drivers of longevity and quality of life for today’s population—such as poverty, insurance gaps, homelessness, and the broad distribution of preventive services. These are hard problems that people can change, and which would benefit from strategic health planning.

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