scholarly journals Does Combined Fractionated Stereotactic Radiotherapy and Immunotherapy Change the Outcome of Recurrent High-Grade Gliomas?

Cureus ◽  
2021 ◽  
Author(s):  
Sezin Yuce Sari ◽  
Burak Yasin Aktas ◽  
Neyran Kertmen ◽  
Aysenur Elmali ◽  
Sadettin Kilickap ◽  
...  
Keyword(s):  
Stereotactic Radiotherapy ◽  
Fractionated Stereotactic Radiotherapy ◽  
High Grade ◽  
High Grade Gliomas

Single dose versus fractionated stereotactic radiotherapy for recurrent high-grade gliomas

1999 ◽  
Vol 45 (5) ◽  
pp. 1133-1141 ◽  
Author(s):  
Kwan H Cho ◽  
Walter A Hall ◽  
Bruce J Gerbi ◽  
Patrick D Higgins ◽  
Warren A McGuire ◽  
...  
Keyword(s):  
Single Dose ◽  
Stereotactic Radiotherapy ◽  
Fractionated Stereotactic Radiotherapy ◽  
High Grade ◽  
High Grade Gliomas

scholarly journals Fractionated stereotactic radiotherapy plus bevacizumab after response to bevacizumab plus irinotecan as a rescue treatment for high-grade gliomas

2015 ◽  
Vol 20 (3) ◽  
pp. 231-238 ◽  
Author(s):  
Antonio José Conde-Moreno ◽  
Raquel García-Gómez ◽  
María Albert-Antequera ◽  
Piedad Almendros-Blanco ◽  
Ramón De Las Peñas-Bataller ◽  
...  
Keyword(s):  
Stereotactic Radiotherapy ◽  
Fractionated Stereotactic Radiotherapy ◽  
High Grade ◽  
Rescue Treatment ◽  
High Grade Gliomas

Fractionated stereotactic radiotherapy boost after post-operative radiotherapy in patients with high-grade gliomas

2003 ◽  
Vol 67 (2) ◽  
pp. 183-190 ◽  
Author(s):  
Brigitta G Baumert ◽  
Johannes Lutterbach ◽  
René Bernays ◽  
J.Bernard Davis ◽  
Frank L Heppner
Keyword(s):  
Stereotactic Radiotherapy ◽  
Fractionated Stereotactic Radiotherapy ◽  
High Grade ◽  
High Grade Gliomas

Fractionated stereotactic radiotherapy using gamma unit after hyperbaric oxygenation on recurrent high-grade gliomas

2006 ◽  
Vol 82 (3) ◽  
pp. 297-303 ◽  
Author(s):  
Kiyotaka Kohshi ◽  
Haruaki Yamamoto ◽  
Ai Nakahara ◽  
Takahiko Katoh ◽  
Masashi Takagi
Keyword(s):  
Stereotactic Radiotherapy ◽  
Hyperbaric Oxygenation ◽  
Fractionated Stereotactic Radiotherapy ◽  
High Grade ◽  
High Grade Gliomas

scholarly journals P14.78 Hypofractionated stereotactic radiotherapy as a salvage therapy for recurrent high-grade gliomas: Single-center experience

2019 ◽  
Vol 21 (Supplement_3) ◽  
pp. iii86-iii86
Author(s):  
T Reynaud ◽  
A Bertaut ◽  
W Farah ◽  
D Thibouw ◽  
G Crehange ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Stereotactic Radiotherapy ◽  
Tumor Control ◽  
High Grade ◽  
Single Center ◽  
Hypofractionated Stereotactic Radiotherapy ◽  
Number Of Patients ◽  
High Grade Gliomas ◽  
Grade Iii

Abstract BACKGROUND The standard of care for patients with recurrent glioblastoma or grade III glioma has not yet been clearly defined and many approaches are available for salvage strategies. These include surgery, re-irradiation or systemic agents. For the treatment of High-Grade (HGG) recurrence by radiation therapy, Hypofractionated Stereotactic Radiotherapy (HFSRT) is an interesting approach because it is minimally invasive, ambulatory, short-lasting and well tolerated. The aim of this study was to evaluate the efficacy of and safety to HFSRT as alvage treatment for patients suffering from HGG relapse in our cancer center and to compare these results with the literature. MATERIAL AND METHODS Between March 2012 and March 2017, 32 consecutive patients (12 women, 20 men) treated in a single-center were retrospectively included included in this study.Grade III gliomas were diagnosed in 14 patients and grade IV in 18 patients. Thirty-four lesions were treated with HFSRT on LINAC. HFSRT delivered a dose of 30 Gy in six fractions of 5Gy (27 Gy in three fractions for one patient) with two or three fractions per week. The treatment plans were normalized to 100% at the isocenter, and prescribed to the 80 % isodose line. Clinical outcomes and prognostic factors were analyzed. RESULTS HFSRT characteristics: The median tumor volume was of 6.1 (0.1–42.2) cm3 and the median PTV was 15 (0.6–67.5) cm3. The median maximum dose, median minimum dose and median mean dose were 38.7 (32.7–42.0) Gy, 29.1 (14.0–32.4) Gy and 35.1 (31.5–37.5) Gy, respectively. Median follow-up was 20.9 months. Median overall survival (OS) following HFSRT was 15.6 months (Median OS for patients patients with GBM and grade III glioma were 8.2 and 19.5 months, respectively; p=0.0496). Progression-free survival (PFS) was 3.7 months (Median PFS for patients with GBM and grade III glioma were 3.6 and 4.5months, respectively; p=0.2424). In multivariate analysis, tumor grade III (p=0.0027), an ECOG status <2 at the time of reirradiation (p=0.0023) and a mean dose >35 Gy (p=0.0055) significantly improved OS. A maximum reirradiation dose above 38 Gy (p=0.0179) was significantly associated with longer PFS. Treatment was well tolerated, no acute toxicity > grade 2 was observed. During the follow-up, ten patients (31.25%) had suspected radionecrosis. In six patients, this suspicion corresponded to tumor progression. For the other patients, radionecrosis was suggested on multi-modal MRI. CONCLUSION HFSRT appears to be a feasible and effective salvage treatment option for recurrent high-grade gliomas, with OS of 15.6 months. Prognostic factors associated with longer OS were a good general state of health and grade III glioma. Dosimetric data suggested that the dose gradient had an impact on tumor control and indicate that a study with dose-escalation is warranted. These results need to be confirmed in a prospective study with a greater number of patients.

scholarly journals EP-1199: Hypofractionated stereotactic radiotherapy as a salvage therapy for recurrent high-grade gliomas

2018 ◽  
Vol 127 ◽  
pp. S669
Author(s):  
T. Reynaud ◽  
N. Vulquin ◽  
W. Farah ◽  
D. Thibouw ◽  
G. Crehange ◽  
...  
Keyword(s):  
Stereotactic Radiotherapy ◽  
Salvage Therapy ◽  
High Grade ◽  
Hypofractionated Stereotactic Radiotherapy ◽  
High Grade Gliomas

scholarly journals Hypofractionated Stereotactic Radiotherapy as a Salvage Therapy for Recurrent High-Grade Gliomas: Single-Center Experience

2018 ◽  
Vol 17 ◽  
pp. 153303381880649 ◽  
Author(s):  
Thomas Reynaud ◽  
Aurélie Bertaut ◽  
Walid Farah ◽  
David Thibouw ◽  
Gilles Crehange ◽  
...  
Keyword(s):  
Stereotactic Radiotherapy ◽  
Salvage Therapy ◽  
High Grade ◽  
Single Center ◽  
Hypofractionated Stereotactic Radiotherapy ◽  
Single Center Experience ◽  
High Grade Gliomas

scholarly journals PD-0532: Stereotactic radiotherapy for recurrent high-grade gliomas: retrospective analysis

2013 ◽  
Vol 106 ◽  
pp. S205
Author(s):  
V. Pinzi ◽  
I.M. Milanesi ◽  
M. Marchetti ◽  
M.L. Fumagalli ◽  
A. Silvani ◽  
...  
Keyword(s):  
Retrospective Analysis ◽  
Stereotactic Radiotherapy ◽  
High Grade ◽  
High Grade Gliomas

Effectiveness of Stereotactic Radiotherapy and Bevacizumab for Recurrent High-Grade Gliomas: A Potential Therapy for Isocitrate Dehydrogenase Wild-Type Recurrent High-Grade Gliomas

2018 ◽  
Vol 114 ◽  
pp. e1138-e1146
Author(s):  
Takayuki Yasuda ◽  
Yoshihiro Muragaki ◽  
Masayuki Nitta ◽  
Kazunari Miyamoto ◽  
Yuko Oura ◽  
...  
Keyword(s):  
Stereotactic Radiotherapy ◽  
Isocitrate Dehydrogenase ◽  
High Grade ◽  
Wild Type ◽  
High Grade Gliomas

scholarly journals RT-31 * SURVIVAL OUTCOMES IN PATIENTS RECEIVING BOTH FRACTIONATED STEREOTACTIC RADIOTHERAPY AND BEVACIZUMAB FOR RECURRENT HIGH GRADE GLIOMA

2014 ◽  
Vol 16 (suppl 5) ◽  
pp. v194-v194
Author(s):  
J. Siglin ◽  
J. Palmer ◽  
C. Champ ◽  
H. Eldredge-Hindy ◽  
J. Glass ◽  
...  
Keyword(s):  
Stereotactic Radiotherapy ◽  
High Grade Glioma ◽  
Fractionated Stereotactic Radiotherapy ◽  
Survival Outcomes ◽  
High Grade
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