scholarly journals Pyloric Gland Metaplasia of the Ileocecal Valve: Clinicopathologic Correlates of Inflammatory Bowel Disease

Cureus ◽  
2017 ◽  
Author(s):  
Daryl Ramai ◽  
Kinesh Changela ◽  
Madhavi Reddy
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Ileocecal Valve ◽  
Pyloric Gland ◽  
Pyloric Gland Metaplasia ◽  
Inflammatory Bowel

Effects of Tumor Necrosis Factor Alpha Inhibitors on Lymph Node and Ileocecal Mucosa-Associated Lymphoid Tissue Architecture in Patients With Inflammatory Bowel Disease

2019 ◽  
Vol 23 (2) ◽  
pp. 115-120
Author(s):  
Virginia E Duncan ◽  
Karen M Chisholm ◽  
M Cristina Pacheco
Keyword(s):  
Inflammatory Bowel Disease ◽  
Lymph Node ◽  
Germinal Center ◽  
Bowel Disease ◽  
Lymphoid Tissue ◽  
Ileocecal Valve ◽  
Tissue Architecture ◽  
Mesenteric Lymph ◽  
Tnfα Inhibitors ◽  
Inflammatory Bowel

Background Antitumor necrosis alpha (TNFα) therapy is often used in the management of patients with inflammatory bowel disease (IBD) and may have effects on lymphoid tissue architecture and function. The goal of our study was to characterize the effects of TNFα inhibitors on mesenteric lymph node and mucosa-associated lymphoid tissue in patients with IBD. Methods We examined lymphoid tissue morphology in IBD patients treated with TNFα inhibitors compared to untreated controls. Intestinal resections from 19 patients (10 anti-TNFα treated and 9 controls) were reviewed. Immunohistochemistry for CD21, CD20, and CD3 was performed on ileocecal valve lymphoid tissue and mesenteric lymph nodes from the resection specimens to assess follicular architecture. Results Relative to control groups, TNFα-treated groups showed less preserved germinal center architecture, evidenced by lower overall semiquantitative scores for follicular architecture. Likewise, the percentage of secondary follicles to total follicles was decreased in patients treated with TNFα blockade. Conclusions Our results suggest that TNFα inhibitors may play a role in disruption of lymphoid germinal center architecture in patients with IBD. Awareness of this disrupted lymphoid morphology when examining histologic sections from patients with IBD treated with TNFα inhibitors may prevent unnecessary studies to exclude a lymphoproliferative disorder.

scholarly journals Ilececum: A Comprehensive Review

2019 ◽  
Vol 2019 ◽  
pp. 1-21
Author(s):  
Shou-jiang Tang ◽  
Ruonan Wu
Keyword(s):  
Inflammatory Bowel Disease ◽  
Terminal Ileum ◽  
Bowel Disease ◽  
Ileocecal Valve ◽  
Screening Colonoscopy ◽  
Gi Bleeding ◽  
Comprehensive Review ◽  
Endoscopic Findings ◽  
Inflammatory Bowel ◽  
Ileal Intubation

For gastrointestinal endoscopists, the ileocecum is the finishing line during colonoscopy and it is identified by three endoscopic landmarks: terminal ileum, ileocecal valve, and the appendiceal orifice. Although ileal intubation is recommended during routine screening colonoscopy, it is not required in most cases of screening colonoscopy. Ileal intubation is indicated in certain circumstances such as suspected inflammatory bowel disease and GI bleeding. There is much pathology that can be observed within the ileocecum. Careful and systematic examination should be stressed during GI endoscopic training and practice. In this review, the authors demonstrate its anatomy, endoscopic findings, and pathologies.

Detection of possible inflammatory bowel disease-related genes using microarray analysis

2001 ◽  
Vol 120 (5) ◽  
pp. A455-A455
Author(s):  
E MANNICK ◽  
M SERRANO ◽  
J BONOMOLO ◽  
M LAU ◽  
J UDALLJR ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Microarray Analysis ◽  
Bowel Disease ◽  
Inflammatory Bowel ◽  
Disease Related Genes
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