scholarly journals Giant Cell Tumour of Clivus: A Rare Case Report

2021 ◽  
Author(s):  
Swapan Shantiram Goswami ◽  
Sonal Jain ◽  
Shalin Nagori
Keyword(s):  
Giant Cell ◽  
Complete Blood Count ◽  
Bone Cyst ◽  
Middle Cranial Fossa ◽  
Lytic Lesion ◽  
Left Internal Carotid Artery ◽  
Normal Range ◽  
Prepontine Cistern ◽  
Rare Case Report ◽  
Mild Anaemia

Giant Cell Tumours (GCT) of the skull is rare, being less than 0.05% of all skeletal tumours. They are usually located in the middle cranial fossa affecting the temporal, sphenoid, petrosal and occipital bone. Clival GCT is rarer and 15 cases are described in the literature. Authors report a case of a female patient aged 20 years, who complained of headache with decrease in vision of left eye. Neurological examination revealed left optic nerve palsy. Laboratory test of Vitamin B12, blood urea, Serum Creatinine, Serum Electrolytes were within normal range. Complete blood count showed mild anaemia. The serum calcium and parathyroid hormones were within normal range. Computed Tomography (CT) scan and Magnetic Resonance Imaging (MRI) were done, which demonstrated expansile destructive lytic lesion involving sphenoid bone and clivus, reaching upto sellar, parasellar regions, sphenoid sinus and left posterior ethmoid sinus, effacing left optic foramina and posteriorly effacing prepontine cistern. The left internal carotid artery was partially encased by the mass. The tumour was partially removed by endoscopic trans-nasal trans-sphenoidal approach. Histopathology confirmed it as a benign GCT. Surgical treatment of clival GCTs are fraught with complication because of its close proximity to vital structures. High vascularity, potential malignant behaviour, inaccessibility and very few published cases preclude a definite outcome of this lesion. Histopathology is necessary to differentiate various lytic lesion like chordoma, aneurysmal bone cyst, invasive pituitary adenoma, chondrosarcoma and brown tumour (parathyroidism).

scholarly journals Palatal Swelling: A Diagnostic Enigma

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Ramalingam Suganya ◽  
Narasimhan Malathi ◽  
Harikrishnan Thamizhchelvan ◽  
Subramaniam Ramkumar ◽  
G. V. V. Giri
Keyword(s):  
Giant Cell ◽  
Bone Cyst ◽  
Giant Cells ◽  
Periosteal Reaction ◽  
Cell Tumor ◽  
Lytic Lesion ◽  
Unique Case ◽  
Bony Lesion ◽  
Primary Neoplasm ◽  
Type Giant

Giant cell tumor (GCT) of bone is a giant-cell-rich bony lesion associated with abundant multinucleated osteoclast-type giant cells. It is a primary neoplasm of bone with characteristic clinical, radiological, and pathological features. It is an expansive and lytic lesion without periosteal reaction and prominent peripheral sclerosis. Giant cells are also seen in other diseases like giant cell granuloma of the jaws, traumatic bone cyst, aneurysmal bone cyst, and jaw tumor of hyperparathyroidism. We present a unique case of GCT of palate in a 30-year-old female.

Aneurysmal Bone Cyst and Giant Cell Tumor of the Foot

1996 ◽  
Vol 17 (8) ◽  
pp. 487-495 ◽  
Author(s):  
Roberto Casadei ◽  
Pietro Ruggieri ◽  
Manuela Moscato ◽  
Andrea Ferraro ◽  
Piero Picci
Keyword(s):  
Giant Cell ◽  
Bone Cyst ◽  
Bone Destruction ◽  
Lytic Lesion ◽  
Joint Involvement ◽  
X Rays ◽  
Giant Cell Tumors ◽  
Pathologic Fractures ◽  
Tarsal Bones ◽  
Aneurysmal Bone Cysts

From 1950 to 1994, 257 cases of benign bone tumors of the foot were treated at the Bone Tumor Center of the Rizzoli Institute. Aneurysmal bone cysts (ABC) and giant cell tumors (GCT) are rare and often they are misdiagnosed. To define the clinical and radiographic features useful for diagnosis, x-rays of 24 ABCs and 21 GCTs of the foot were reviewed. Adding our series to the cases reported in the literature, the only important clinical data that emerged was the average age of patients affected by ABC and GCT (15 and 27 years, respectively). ABCs localized in small tarsal bones were rare (6%), whereas 19% of GCTs were found in this site. The eccentric, round shape of a lytic lesion was more characteristic of GCT. An aggressive pattern of radiographic bone destruction was observed more frequently in GCT than in ABC ( P = 0.01). Septation was seen in both tumors. Typical of ABC was a sharp and trabeculated margin, whereas GCT had an ill-defined edge with normal cancellous bone ( P = 0.007). The growth of ABCs often expanded the cortex, while GCTs eroded, thinned, and broke the cortical bone ( P = 0.001). A saucerized cortex was observed only in ABCs. A bony shell was more characteristic of ABC than of GCT ( P = 0.002). Pathologic fractures (67%) and joint involvement, evaluated by computed tomography and magnetic resonance imaging (83%), were more frequent in GCTs, whereas fluid levels were more frequently observed in ABCs (47%). The majority of the tumors were stage 2, but GCTs represented 70% of stage 3 aggressive lesions.

Concomitant Peripheral Giant Cell Lesion and Traumatic Bone Cyst in the Mandible: a Rare Case Report

2018 ◽  
Vol 126 (3) ◽  
pp. e81
Author(s):  
Bianca De Bem Prunes ◽  
Júlia Silveira Nunes ◽  
Natália Batista Daroit ◽  
João Julio Da Cunha Filho ◽  
Márcia Gaiger De Oliveira ◽  
...  
Keyword(s):  
Case Report ◽  
Giant Cell ◽  
Rare Case ◽  
Bone Cyst ◽  
Giant Cell Lesion ◽  
Rare Case Report

scholarly journals A rare case report of aneurysmal bone cyst involving the roof of the orbit

2013 ◽  
Vol 02 (02) ◽  
pp. 203-206
Author(s):  
Chugh Ashish ◽  
Chaudhari Priyanka ◽  
Gandhi Bhooshan ◽  
Charandeep Gandhoke
Keyword(s):  
Aneurysmal Bone Cyst ◽  
Bone Cyst ◽  
Visual Disturbance ◽  
Vascular Lesion ◽  
Lytic Lesion ◽  
Histopathological Diagnosis ◽  
Orbital Roof ◽  
Rare Case Report ◽  
The Right ◽  
Enhanced Computed Tomography

Abstract Aneurysmal bone cyst (ABC) is a benign, tumor like, multi-cystic vascular lesion that causes destruction of the cortical bone. It usually involves the metaphysis of long bones and spine (posterior elements). ABC arising in the orbit constitutes less than 0.25% of all reported cases. We report a 5-year-old girl who presented with painless right sided proptosis without any visual disturbance, which was gradual in onset. Contrast enhanced computed tomography and magnetic resonance imaging scans of the orbit were suggestive of an expansile bony lytic lesion in the roof of the right orbit. Frontal craniotomy followed by the supra-orbital osteotomy was carried out. The entire tumor-like mass was removed piece-meal. Histopathological diagnosis was “a solid variant of ABC of the orbital roof.” Post-operative course was satisfactory and the patients eye symptoms improved.

scholarly journals Chondroblastoma: An Update

2017 ◽  
Vol 141 (6) ◽  
pp. 867-871 ◽  
Author(s):  
Wenqian Chen ◽  
Lisa M. DiFrancesco
Keyword(s):  
Aneurysmal Bone Cyst ◽  
Bone Cyst ◽  
Cyst Formation ◽  
Giant Cells ◽  
Lytic Lesion ◽  
Primary Bone Tumor ◽  
Hemosiderin Deposition ◽  
Secondary Aneurysmal Bone Cyst ◽  
Primary Bone ◽  
Chondroblastic Osteosarcoma

Chondroblastoma is a rare primary bone tumor of young people that typically arises in the ends of the long bones. Radiologic investigations show a small, circumscribed, lytic lesion. The tumor is characterized histologically by the proliferation of chondroblasts along with areas of mature cartilage, giant cells, and occasionally, secondary aneurysmal bone cyst formation. Chondroblastoma, however, may also present with atypical features, such as prominent hemosiderin deposition, numerous giant cells, or the presence of a large aneurysmal bone cyst component. Malignant entities such as clear cell chondrosarcoma and chondroblastic osteosarcoma must also be considered. Recently, immunohistochemical stains such as DOG1 and SOX9 have been described in chondroblastoma, and K36M mutations in either the H3F3A or H3F3B genes have also been identified. While generally regarded as a benign entity, chondroblastoma manifests an intermediate type of behavior, given its ability to recur locally, and rarely, metastasize.

Medial malleolar osteotomy for intralesional curettage and bone grafting of primary aneurysmal bone cyst of the talus

2021 ◽  
Vol 14 (5) ◽  
pp. e242452
Author(s):  
Sujit Tripathy ◽  
Paulson Varghese ◽  
Sibasish Panigrahi ◽  
Lubaib Karaniveed Puthiyapura
Keyword(s):  
Aneurysmal Bone Cyst ◽  
Cystic Lesion ◽  
Articular Surface ◽  
Weight Bearing ◽  
Bone Cyst ◽  
Lytic Lesion ◽  
Intralesional Curettage ◽  
Medial Malleolar Osteotomy ◽  
Fluid Levels

Access to the cystic lesion of the talar body without damage to the articular surface is difficult. This case report is about a 23-year-old man who had a symptomatic huge cystic lesion in the left-sided talus bone. Radiograph and CT scan showed an expansile lytic lesion within the talar body. The MRI revealed a well-defined lesion with fluid-fluid levels. The needle biopsy aspirate was haemorrhagic, and hence a diagnosis of the aneurysmal bone cyst was made. As the lesion was beneath the talar dome with an intact neck and head, a medial approach with medial malleolar osteotomy was performed. The lesion was curetted out, and the cavity was filled up with a morselised bone graft. The limb was splinted for 6 weeks, and complete weight bearing was started after 3 months. At 1-year follow-up, the lesion was found to be healed up, and the patient was pain-free with no recurrence.

scholarly journals Pelvic Girdle Reconstruction Based on Spinal Fusion and Ischial Screw Fixation in a Case of Aneurysmal Bone Cyst

Sarcoma ◽  
2003 ◽  
Vol 7 (3-4) ◽  
pp. 177-182 ◽  
Author(s):  
Matthias Honl ◽  
Florian Westphal ◽  
Volker Carrero ◽  
Michael Morlock ◽  
Karsten Schwieger ◽  
...  
Keyword(s):  
Aneurysmal Bone Cyst ◽  
Iliac Crest ◽  
Screw Fixation ◽  
Pelvic Ring ◽  
Bone Cyst ◽  
Pedicle Screws ◽  
Lytic Lesion ◽  
Titanium Plate ◽  
Lower Lumbar Spine ◽  
Lower Lumbar

A case of lytic lesion of the pelvis in a 23-year-old woman is presented. A biopsy led to the diagnosis aneurysmal bone cyst (ABC). Due to the histologically very aggressive growth of the tumor, a low malignant osteosarcoma could not be excluded. In an initial operation the tumour, affecting the sacrum, the iliac crest and the lower lumbar spine was resected. Temporary restabilisation of the pelvic ring was achieved by a titanium plate. The histological examination of the entire tumour confirmed the diagnosis ABC. After 6 months, the MRI showed no recurrence. The observed tilt of the spine to the operated side on the sacral base prompted a second surgical procedure: a transpedicular fixation of L5 and L4 was connected via bent titanium stems to the ischium, where the fixation was achieved by two screws. This construction allowed the correction of the base angle and yielded a stable closure of the pelvic ring. The patient has now been followed for 6 years: the bone grafts have been incorporated and, in spite of radiological signs of screw loosening in the ischium, the patient is fully rehabilitated and free of symptoms. Pedicle screws in the lower spine can be recommended for fixation of a pelvic ring discontinuity.

scholarly journals Evaluation of anaemia

2017 ◽  
Vol 5 (10) ◽  
pp. 4481 ◽  
Author(s):  
Suchita V. Ingale ◽  
Milind P. Ullewar ◽  
Vikas C. Ingale ◽  
Jayshree J. Upadhye
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Complete Blood Count ◽  
Severe Anaemia ◽  
Peripheral Smear ◽  
Pathology Laboratory ◽  
Mild Anemia ◽  
Normocytic Normochromic Anaemia ◽  
Moderate Anemia ◽  
Mild Anaemia

Background: Often, the first test used to diagnose anemia is a complete blood count (CBC). It determines the number, size, volume, and hemoglobin content of red blood cells. Peripheral smear is done for typing of anaemia. Such evaluation is necessary for proper treatment.Methods: A retrospective study was done in 300 anaemic patients at Shakuntala pathology laboratory, Nagpur. Patients were randomly selected including males and females. CBC and peripheral smear were analyzed.Results: Out of total 300 patients evaluated, the prevalence of anaemia was quite significant in females 225 (75%) than males 75 (25%). 66 females (22%) had mild anemia while 129 females (43%) had moderate anemia and 30 females (10%) had severe anaemia 36 males (12%) had mild anaemia, 30 males (10%) had moderate anaemia while 9 males (3%) had severe anaemia. In morphology of red blood cells, normocytic normochromic anaemia was seen in 132 (44%) females and in 45 (15%) of males. Microcytic hypochromic anaemia was seen in 90 (30%) females and 27 (9%) males. Macrocytic anaemia was seen in 3 (1%) females and 3 (1%) males.Conclusions: Prevalence of anaemia is quite high in females than males. Also, the severity of anaemia is more in females than males. So, heath programmes should be directed more towards females since adolescent age.

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