Placental Pathology in a COVID-19 Positive Patient with Abruptio Placentae- A Case Report

The effects of Severe Acute Respiratory Distress Syndrome-Associated Coronavirus-2 (SARS-CoV-2) on the placental tissue are still being explored. Whether these placental changes result in adverse foeto-maternal outcome is an aspect that needs to be understood. This is a report of 32-year-old pregnant woman who presented with Antepartum Haemorrhage (APH) and decreased foetal movements. She was also diagnosed to be positive for the SARS-CoV-2. The patient had abruptio placentae unrelated to pre-eclampsia. On histopathological examination, the umbilical cord showed funisitis with increased perivillous fibrin deposition on section from foetal and maternal surface of the placenta. Though the foetus was stillborn, with timely management the maternal outcome was not compromised.

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Acute respiratory distress syndrome in a pregnant woman with systemic lupus erythematosus: a case report

Lupus ◽

10.1177/0961203314548713 ◽

2014 ◽

Vol 23 (14) ◽

pp. 1528-1532 ◽

Cited By ~ 4

Author(s):

Y-J A Chen ◽

J-J Tseng ◽

M-J Yang ◽

Y-P Tsao ◽

H-Y Lin

Keyword(s):

Systemic Lupus Erythematosus ◽

Acute Respiratory Distress Syndrome ◽

Case Report ◽

Pregnant Woman ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Lupus Erythematosus ◽

Distress Syndrome ◽

Systemic Lupus

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Extensive Perivillous Fibrin and Intervillous Histiocytosis in a SARS-CoV-2 Infected Placenta From an Uninfected Newborn: A Case Report Including Immunohistochemical Profiling

Pediatric and Developmental Pathology ◽

10.1177/10935266211025122 ◽

2021 ◽

pp. 109352662110251

Author(s):

James Roberts ◽

Jeanette D Cheng ◽

Elizabeth Moore ◽

Carla Ransom ◽

Minhui Ma ◽

...

Keyword(s):

Risk Factors ◽

Case Report ◽

Gestational Age ◽

Small For Gestational Age ◽

Immunohistochemical Staining ◽

Placental Pathology ◽

Fibrin Deposition ◽

Placental Infection ◽

Fetal Infection

Placental infection by SARS-CoV-2 with various pathologic alterations reported. Inflammatory findings, such as extensive perivillous fibrin deposition and intervillous histiocytosis, have been postulated as risk factors for fetal infection by SARS-CoV-2. We describe the placental findings in a case of a 31-year-old mother with SARS-CoV-2 infection who delivered a preterm female neonate who tested negative for SAR-CoV2 infection. Placental examination demonstrated a small for gestational age placenta with extensive intervillous histiocytosis, syncytiotrophoblast karyorrhexis, and diffuse intervillous fibrin deposition. Immunohistochemical staining demonstrated infection of the syncytiotrophoblasts by SARS-CoV-2 inversely related to the presence of intervillous histiocytes and fibrin deposition. Our case demonstrates that despite extensive placental pathology, no fetal transmission of SARS-CoV-2 occurred, as well as postulates a relationship between placental infection, inflammation, and fibrin deposition.

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