This chapter covers gynaecological cancers and includes information on cervical, endometrial, ovarian, and vaginal and vulval cancers. It also covers epidemiology, molecular biology and pathology. Surgical management focuses on risk adapted diagnostic and therapeutic procedures and includes laparoscopic lymph node and tumour surgery. The role of primary, adjuvant or neoadjuvant radiotherapy is described consisting of external beam therapy or (image guided) brachytherapy or combined treatment, also as concomitant radiochemotherapy. Medical management is outlined comprising cytotoxic chemotherapy, hormonal therapy and targeted drugs with their different role in neoadjuvant, adjuvant and primary treatment. Multidisciplinary management is described for complex cases of cervix, endometrium and ovarian cancer.