scholarly journals Single-step Syznthesis of Coenzyme Q0

2019 ◽  
pp. 1-4
Author(s):  
Yi-Yu Yan ◽  
Yong-Fu Qiu ◽  
Tian-Li Zhang ◽  
Yu-Bei He ◽  
Shi Qi ◽  
...  
Keyword(s):  
Transition Metal ◽  
Ammonium Persulfate ◽  
Single Step ◽  
New Method ◽  
Metal Free ◽  
One Step ◽  
Coenzyme Q0

A new method for the preparation of 2-methyl-5,6-dimethoxy-1,4-benzoquinone (Coenzyme Q0) was developed. This improved process in one step by the oxidation of 3,4,5-trimethoxytoluene to coenzyme Q0 by simple oxidation using potassium or ammonium persulfate under transition -metal free conditions.

Transition Metal-free Single Step Approach for Arylated Pyrazolopyrimidinones and Quinazolinones Using Benzylamines/Benzylalcohols/Benzaldehydes

2017 ◽  
Vol 2 (17) ◽  
pp. 4963-4968 ◽  
Author(s):  
Abhinandan D. Hudwekar ◽  
G. Lakshma Reddy ◽  
Praveen K. Verma ◽  
Sorav Gupta ◽  
Ram A. Vishwakarma ◽  
...  
Keyword(s):  
Transition Metal ◽  
Single Step ◽  
Metal Free

Direct and metal-free oxidative amination of sp3 C–H bonds for the construction of 2-hetarylquinazolin-4(3H)-ones

2016 ◽  
Vol 3 (9) ◽  
pp. 1096-1099 ◽  
Author(s):  
Huanhuan Liu ◽  
Tianran Zhai ◽  
Shiteng Ding ◽  
Yalei Hou ◽  
Xiangyu Zhang ◽  
...  
Keyword(s):  
Transition Metal ◽  
Functional Group ◽  
New Method ◽  
Oxidative Amination ◽  
Metal Free ◽  
Mild Conditions

New method for synthesis of 2-hetarylquinazolin-4(3H)-ones from 2-aminobenzamides and (2-azaaryl)methanes under transition-metal free conditions, featuring a wide substrate scope with a broad range of functional group tolerance under mild conditions.

Transition-Metal-Free, Intermolecular Azidoheteroarylation of Alkenes: Efficient Access to β-Azidoalkylated Quinoxalinones and Preliminary Antifungal Evaluation Against Magnaporthe grisea

Synthesis ◽  
2020 ◽  
Vol 52 (16) ◽  
pp. 2395-2409
Author(s):  
Weiwei Qin ◽  
Zhaodong Li ◽  
Yiming Du ◽  
Yue Chen ◽  
Yun-Lin Liu
Keyword(s):  
Transition Metal ◽  
Magnaporthe Grisea ◽  
Single Step ◽  
Domino Reaction ◽  
Efficient Synthesis ◽  
Metal Free ◽  
Efficient Access ◽  
First Time ◽  
Antibacterial Evaluation ◽  
Addition Pathway

An efficient, PhI(OAc)2-mediated, radical azidoheteroarylation of alkenes under transition-metal-free conditions is reported by employing TMSN3 and quinoxalin-2(1H)-ones as coupling partners. This domino reaction allows an efficient synthesis of valuable orangoazides containing quinoxalin-2(1H)-one derivatives and could be extended to phosphinyl-alkylated quinoxalin-2(1H)-one in a single step in moderate to excellent yields under mild conditions, as demonstrated by the preliminary antibacterial evaluation against Magnaporthe grisea for the first time. Mechanistic studies revealed that this transformation undergoes a cascade addition pathway controlled by a polar radical.

Transition-metal free C(sp2)–C(sp2) bond formation: arylation of 4-aminocoumarins using arynes as an aryl source

2019 ◽  
Vol 17 (40) ◽  
pp. 9014-9025 ◽  
Author(s):  
Abhilash Sharma ◽  
Pranjal Gogoi
Keyword(s):  
Transition Metal ◽  
Bond Formation ◽  
Single Step ◽  
Metal Catalyst ◽  
Metal Free ◽  
Synthetic Strategy

A mild, efficient and transition-metal free synthetic strategy has been developed for the α-arylation of 4-aminocoumarins using arynes as an aryl source. This synthetic strategy proceeds via C(sp2)–C(sp2) bond formation between 4-aminocoumarins and aryne precursors in a single step in the absence of a metal-catalyst.

Transition-metal free direct difluoromethylthiolation of electron-rich aromatics with difluoromethanesulfonyl chloride

2017 ◽  
Vol 4 (2) ◽  
pp. 232-235 ◽  
Author(s):  
Xia Zhao ◽  
Aoqi Wei ◽  
Tianjiao Li ◽  
Zhiyang Su ◽  
Jun Chen ◽  
...  
Keyword(s):  
Transition Metal ◽  
New Method ◽  
Metal Free

A new method for phosphine-mediated difluoromethylthiolation of indoles and other electron-rich aromatics using difluoromethanesulfonyl chloride was developed.

Synthesis of 1,4-diazepinone derivatives via a domino aza-Michael/SN2 cyclization of 1-azadienes with α-halogenoacetamides

2020 ◽  
Vol 18 (6) ◽  
pp. 1082-1086 ◽  
Author(s):  
Chunhao Yuan ◽  
Hui Zhang ◽  
Mengna Yuan ◽  
Lei Xie ◽  
Xiaoqun Cao
Keyword(s):  
Transition Metal ◽  
Metal Free ◽  
One Step

A novel cyclization of N-alkoxy α-halogenoacetamides with N-sulfonyl-1-aza-1,3-butadienes has been developed for the efficient preparation of 1,4-diazepinones in one step under transition metal-free conditions.

ChemInform Abstract: Transition-Metal-Free Oxidative Amidation of Benzyl Alcohols with Amines Catalyzed by NaI: A New Method for the Synthesis of Benzamides.

ChemInform ◽  
2015 ◽  
Vol 46 (10) ◽  
pp. no-no
Author(s):  
Meghdad Karimi ◽  
Dariush Saberi ◽  
Kobra Azizi ◽  
Marzban Arefi ◽  
Akbar Heydari
Keyword(s):  
Transition Metal ◽  
New Method ◽  
Benzyl Alcohols ◽  
Metal Free ◽  
Oxidative Amidation

Expedient one-step synthesis of nitrogen stilbene analogs by transition metal-free hydroamination of arylacetylenes with pyrroles

Tetrahedron ◽  
2012 ◽  
Vol 68 (7) ◽  
pp. 1963-1971 ◽  
Author(s):  
Marina Yu. Dvorko ◽  
Elena Yu. Schmidt ◽  
Tatyana E. Glotova ◽  
Dmitrii A. Shabalin ◽  
Igor' A. Ushakov ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Free ◽  
One Step ◽  
Stilbene Analogs

scholarly journals Easy Access To Allylic Sulfones Through Transition Metal-Free Hydrosulfonylation Of Allenes

2021 ◽  
Author(s):  
Lucas Pages ◽  
Sebastien Lemouzy ◽  
Marc Taillefer ◽  
Florian Monnier
Keyword(s):  
Transition Metal ◽  
Good Yield ◽  
Easy Access ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Metal Free ◽  
Brönsted Acid ◽  
One Step

A Brønsted acid-mediated addition of (hetero)aryl and (cyclo)alkyl sodium sulfinates to <i>N</i>-allenyl derivatives is described under very smooth conditions. This reaction provided a practical and efficient protocol for the synthesis of allylic sulfones in an atom- and step-economic fashion. In addition, an one-step double hydrosulfonylation has also been demonstrated, affording the corresponding 1,3-disulfone in to good yield.<br>

Transition-Metal-Free One-Step Synthesis of Ynamides

2019 ◽  
Vol 84 (7) ◽  
pp. 4458-4466 ◽  
Author(s):  
Xianzhu Zeng ◽  
Yongliang Tu ◽  
Zhenming Zhang ◽  
Changming You ◽  
Jiao Wu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Free ◽  
One Step
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