Can Combinations of Non-Invasive Parameters Replace Liver Biopsy in the Diagnosis of Hepatic Fibrosis in Egyptian Patients with Chronic Hepatitis C

CONTEXT: Hepatitis C is an important cause of chronic liver disease worldwide. The grading of hepatic fibrosis in chronic hepatitis C is important for better clinical management. However, until now, liver biopsy is the only test accepted for this purpose, despite their contraindications and complications. New methods for non-invasive assessment of hepatic fibrosis are under investigation. One proposal is the Doppler ultrasound, as a non-invasive, widely available and inexpensive. OBJECTIVE: To compare Doppler parameters of portal vein in patients with chronic hepatitis C with a healthy control group and to correlate these parameters with fibrosis degree obtained by liver biopsy. METHODS: Fifty patients with chronic hepatitis C submitted to liver biopsy and 44 healthy controls had Doppler of the portal vein performed, with the calculation of the portal venous index. We conducted a comparison between the averages of the two groups of portal venous index. For the correlation between portal venous index and fibrosis was employed the Spearman test. RESULTS: There was a difference between the average portal venous index between controls (0.33 ± 0.07) and patients (0.23 ± 0.09) with P<0.001. No difference was observed between the portal venous index in patients with chronic hepatitis C who have significant fibrosis or not. The correlation between the portal venous index and fibrosis degree was reverse and moderate (r =-0.448 P<0.001). The area under the ROC curve was 78.4% (95% CI: 68.8% to 88%). The cutoff for the portal venous index was 0.28 with sensitivity of 73.5% and specificity of 71.1%. CONCLUSION: The portal venous index was useful in distinguishing healthy patients from patients with CHC. However, there was no significant difference in the quantification of degree of fibrosis.

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Fibrogenic/Angiogenic Linker for Non-Invasive Assessment of Hepatic Fibrosis Staging in Chronic Hepatitis C Among Egyptian Patients

Annals of Hepatology ◽

10.5604/01.3001.0010.5276 ◽

2017 ◽

Vol 16 (6) ◽

pp. 862-873 ◽

Cited By ~ 1

Author(s):

EL-Shahat A. Toson ◽

Gamal E. Shiha ◽

Asmaa E. Abdelgaleel

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Hepatic Fibrosis ◽

Non Invasive ◽

Egyptian Patients ◽

Fibrosis Staging

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Evaluation of Serum Fibrosis Markers (CTGF) and (IL-17) versus Liver Biopsy for Detection of Hepatic Fibrosis in Egyptian Patients with Chronic Hepatitis C = تقييم دلالات التليف (سي تي جي اف) و(إنترلوكين-17) بمصل الدم مقابل أخذ جزعة كبدية للكشف عن تليف الكبد في المرضى المصريين المصابين بالتهاب الكبد المزمن (ج)

Ain Shams Medical Journal ◽

10.12816/0051506 ◽

2015 ◽

Vol 66 (1-3) ◽

pp. 205-215

Author(s):

سمر كمال قاسم ◽

سناء محرم كمال ◽

مها محمد سلام ◽

ليلى نابغ محمد ◽

حنان حسين شحاتة ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Liver Biopsy ◽

Chronic Hepatitis C ◽

Hepatic Fibrosis ◽

Egyptian Patients

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Nem invazív fibrosisdiagnosztika hepatitis C-vírus-infekcióban: szerepe a kezelés indikációjában, követésében és a prognózis megítélésében

Orvosi Hetilap ◽

10.1556/650.2015.30173 ◽

2015 ◽

Vol 156 (21) ◽

pp. 855-861 ◽

Cited By ~ 1

Author(s):

Alajos Pár ◽

Áron Vincze ◽

Gabriella Pár

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Liver Biopsy ◽

Chronic Hepatitis C ◽

Antiviral Treatment ◽

Hepatitis C Virus Infection ◽

Non Invasive ◽

Chronic Hepatitis C Virus

Chronic hepatitis C virus infection associated with necroinflammation predisposes to liver fibrosis and cirrhosis, which lead to severe end-stage complications. Staging of fibrosis is of basic importance for the indication of antiviral treatment, for monitoring the response and predicting the prognosis of patients with hepatitis C virus related liver disease. Since liver biopsy, the “gold standard” diagnosis of fibrosis is invasive and it has some other limitations, non-invasive methods have been developed and widely used in the clinical practice. Serum biomarkers and physical approaches measuring liver stiffness by elastography as well as combination algorithms have been gradually been integrated into guidelines resulting in a reduction of the need for liver biopsy. The authors review these non-invasive fibrosis markers and discuss their role in the indication of treatment, follow-up, and assessment of prognosis of patients with chronic hepatitis C virus infection. Orv. Hetil., 2015, 156(21), 855–861.

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