Cerebral Toxoplasmosis in an HIV Patient with Fatal Outcome

Combined tracheal and esophageal atresia with fatal outcome

Ultraschall in der Medizin - European Journal of Ultrasound ◽

10.1055/s-0036-1587907 ◽

2016 ◽

Vol 37 (S 01) ◽

Author(s):

S Kehl ◽

TM Völkl ◽

F Baier ◽

T Hildebrandt ◽

MW Beckmann ◽

...

Keyword(s):

Esophageal Atresia ◽

Fatal Outcome

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Cranial crassicaudiasis in two coastal dolphin species from South Africa is predominantly a disease of immature individuals

Diseases of Aquatic Organisms ◽

10.3354/dao03468 ◽

2020 ◽

Vol 139 ◽

pp. 93-102 ◽

Cited By ~ 3

Author(s):

MF Van Bressem ◽

P Duignan ◽

JA Raga ◽

K Van Waerebeek ◽

N Fraijia-Fernández ◽

...

Keyword(s):

South Africa ◽

Bone Development ◽

Bottlenose Dolphins ◽

Fatal Outcome ◽

Population Level ◽

Cape Coast ◽

Osteolytic Lesions ◽

Immune Mediated ◽

Significant Difference ◽

The Difference

Crassicauda spp. (Nematoda) infest the cranial sinuses of several odontocetes, causing diagnostic trabecular osteolytic lesions. We examined skulls of 77 Indian Ocean humpback dolphins Sousa plumbea and 69 Indo-Pacific bottlenose dolphins Tursiops aduncus, caught in bather-protecting nets off KwaZulu-Natal (KZN) from 1970-2017, and skulls of 6 S. plumbea stranded along the southern Cape coast in South Africa from 1963-2002. Prevalence of cranial crassicaudiasis was evaluated according to sex and cranial maturity. Overall, prevalence in S. plumbea and T. aduncus taken off KZN was 13 and 31.9%, respectively. Parasitosis variably affected 1 or more cranial bones (frontal, pterygoid, maxillary and sphenoid). No significant difference was found by gender for either species, allowing sexes to be pooled. However, there was a significant difference in lesion prevalence by age, with immature T. aduncus 4.6 times more likely affected than adults, while for S. plumbea, the difference was 6.5-fold. As severe osteolytic lesions are unlikely to heal without trace, we propose that infection is more likely to have a fatal outcome for immature dolphins, possibly because of incomplete bone development, lower immune competence in clearing parasites or an over-exuberant inflammatory response in concert with parasitic enzymatic erosion. Cranial osteolysis was not observed in mature males (18 S. plumbea, 21 T. aduncus), suggesting potential cohort-linked immune-mediated resistance to infestation. Crassicauda spp. may play a role in the natural mortality of S. plumbea and T. aduncus, but the pathogenesis and population level impact remain unknown.

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Adenoid Cystic Carcinoma of Lacrimal Gland

JMS SKIMS ◽

10.33883/jms.v15i1.124 ◽

2012 ◽

Vol 15 (1) ◽

pp. 76-77

Author(s):

Mohd Athar ◽

K S Sodhi ◽

S Kala ◽

R K Maurya ◽

S Chauhan ◽

...

Keyword(s):

Local Recurrence ◽

Natural History ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Hard Palate ◽

Clinical Course ◽

Fatal Outcome ◽

Minor Salivary Glands ◽

Adenoid Cystic ◽

History Of

Adenoid cystic carcinoma is a relatively uncommon tumour of salivary, glands and is characterised by a prolonged clinical course and a fatal outcome. It was first described as `cylindroma' by Billroth in 1859. Half of these tumors occur in glandular tissues other than the major salivary glands; principally in the hard palate, but they can also arise in the tongue and minor salivary glands. Unusual locations include the external auditory canal, nasopharynx, lacrimal glands, breast, vulva, esophagus, cervix and Cowper glands. The long natural history of this tumor and its tendency for local recurrence are well known. JMS 2012;15(1):76-77.

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Complications of systemic cytomegalovirus infection in therapy refracter Hodgkin’s lymphoma

Orvosi Hetilap ◽

10.1556/oh.2012.29364 ◽

2012 ◽

Vol 153 (19) ◽

pp. 751-755 ◽

Cited By ~ 2

Author(s):

Gábor Irsai ◽

Tatjana Tampu-Kiss ◽

Balázs Dezső ◽

Zsófia Miltényi ◽

Árpád Illés ◽

...

Keyword(s):

Hodgkin's Disease ◽

Tumor Invasion ◽

Cytomegalovirus Infection ◽

Hodgkin’S Disease ◽

Fatal Outcome ◽

Giant Cells ◽

Atypical Cell ◽

Allogenic Stem Cell Transplantation ◽

Multiple Organs ◽

Large Atypical Cell

Cytomegalovirus infection related changes frequently remain masked by local symptoms of tumor invasion or therapeutic side effects in cancer patients. The spectrum of cytomegalovirus manifestations, however, can be highly varied and may contribute to the failure of different organs with fatal outcome. The case of a 29-year-old female patient is presented who obtained polychemotherapy and allogenic stem cell transplantation following the diagnosis of classical Hodgkin’s disease. Despite intensified treatment, only partial response could be achieved and the outcome of the disease was death. Postmortem examination revealed regressive lymph node infiltration as well as nodular liver and spleen manifestations of classical Hodgkin’s disease. In addition, parenchymal tissues (lung, kidneys, small intestine, liver, pancreas and ovaries) showed the classical morphology of widespread cytomegalovirus infection. Bilateral enlargement of the ovaries was caused by a partially necrotic giant cell proliferation in the subepithelial cortex. CD30-negativity and cytomegalovirus antigen positivity of the large atypical cell infiltrate supported the diagnosis of cytomegalia oophoritis with morphological overlap between cytomegalovirus-infected giant cells and residual Hodgkin-Reed-Sternberg cells. Further to the cytopathic effect in multiple organs, significant hemophagocytosis was also observed in the spleen, liver and bone marrow. In summary, active cytomegalovirus infection may be a major cause of multi-organ failure in the immunosuppressed oncohematological patient. Careful postmortem analysis demonstrated both the activity of the viral infection and the efficacy of the anti-viral treatment, when applied. Orv. Hetil., 2012, 153, 751–755.

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