STUDY THE DYSLIPIDEMIA AND THE EFFECTIVENESS OF TREATMENT IN PATIENT AFTER RENAL TRANSPLANTATION AT HUE CENTRAL HOSPITAL

Objectives: Survey proportion of dyslipidemia and related factors in after kidney transplantation. Assess the efficancy and side effects of atorvastatin in hyperlipidemia after renal transplantation. Materials and Methods: 43 patients received a kidney transplantation at Hue central Hospital from 06/2013-08/2015.And 26 hyperlipidemia renal transplant recipents was administered with atorvastatin 10mg/day for a period of 2 months base on guideline treatment of NCEC 1991 (National Cholesterol Education Council). A Cross-sectional and prospective study. Results: new-onset dyslipidemia incidence after renal transplantation was 97.7%. Dyslipidemiatreatement base on recommend NCECwas 60.5%.The regimen 1(Neoral+ Cellcept+Prednisolon) and 2 (Prograf+ Cellcept+Prednisolon) have similar effect on change serum lipid before and after transplantation 1 month (p<0.05).On average, serum total cholesterol and serum LDL cholesterol and triglyceride significantly decreased after atorvastatin therapy (p<0.05). Whereas, serum HDL cholesterol also decreased. Renal function, creatinin clearance, transamina, creatinin phosphokinase, CRP, fasting glucose, urine protein without significant changes during the period on atorvastatin. Adverse effects were reported in three cases (2 case increase transamin and 1 case increase creanin phosphokinase). But there was no evidence of myopathy, including myalgia. All events were mild and treatment did not need to be discontinued in any of the case. Elevated transamina and CK spontaneous resolution, even the Atorvastatin is continued. Conclusion: Dyslipidemia met with high rates after transplant and showed no difference in the regimens using immunosuppressive drugs cause this disorder. Treatment with atorvastatin 10 mg / day has remarkable effect of dyslipidemia in patients after renal transplantation. Key words: renal transplantation, immunosuppressive drugs, dyslipidemia.

STUDY THE STATUS USING IMMUNOSUPRESSANTS, SIDE EFFECTS OF IMMUNOSUPRESSANTS AND COMPLICATIONS ON RENAL TRANSPLATATION PATIENTS

Renal transplantation is the most effective therapy in treatment the end stage renal disease. Donated kidney can be transplanted from living donors or brain dead donors renal transplantation reduces the mortality and life quality versus hemodialysis. HLA gene is the most basic examination in renal transplantation. Objectives: to study the status of using the immunosupressants, side effects of immunosuppressants and complications on renal transplantation patients. Materials and Methods: 66 patients at Hue Centre Hospital from 11/2013 - 9/2014 . A Cross-sectional and prospective study. Results and conclusions: 3 patients had acute renal rejection and 4 patients had chronic renal rejection. The complications in the groups transphlanted over 1 years were diabietes, diarrhea, varicella, thrombopenia. Hyperuricemia was 39.4%, drugs hepatitis was 12.1%. After renal transplantation, were 13.6% had urinary infections, no case of heart failure was domanted. Key words: renal transplantation, immunosuppressants, complications.