Neuroendocrine Breast Carcinoma: Case Report and Review of the Literature

Primary breast carcinoma with neuroendocrine features is an uncommon presentation of mammary cancers. The authors present a case of a rapidly growing breast mass that raised many differential diagnoses. The diagnosis in this case was challenging. Extensive clinical assessment, radiological imaging, nuclear scans, pathological evaluations, and series of multidisciplinary meetings were utilized to reach the diagnosis of neuroendocrine breast carcinoma.

Primary breast carcinoma en cuirasse. A rare presentation of an aggressive malignancy and review of the literature

Breast carcinoma en cuirasse is a very rare form of cutaneous metastases of breast cancer. The clinical presentation is that of a diffuse indurated carcinomatous infiltration of the skin and subcutaneous tissues of the mammary region and the anterior aspect of the chest. In most cases, breast carcinoma en cuirasse develops post-mastectomy and represents a dramatic presentation of an aggressive tumor associated with a dismal prognosis. Because of the rarity of this type of malignancy, the optimal approach to treatment has not been clearly defined. The systemic treatment has been associated with limited efficacy, and the primary goal is palliative care and preservation of the quality of life through skin-directed therapies. Herein, a very rare case of primary breast carcinoma en cuirasse is presented, along with a review of the literature. Early diagnosis and prompt treatment of any potential skin metastases of breast cancer are essential to prevent the catastrophic natural progression of the disease.