cpg dinucleotide methylation
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scholarly journals Activation of stably silenced genes by recruitment of a synthetic de-methylating module

2021 ◽  
Author(s):  
Wing Fuk Chan ◽  
Christine R. Keenan ◽  
Timothy M. Johanson ◽  
Rhys S. Allan
Keyword(s):  
Catalytic Domain ◽  
Surface Protein ◽  
Transcriptional Activators ◽  
Erythroid Cells ◽  
Current Generation ◽  
Non Coding Rna ◽  
Activation System ◽  
Cpg Dinucleotide ◽  
High Level ◽  
Cpg Dinucleotide Methylation

AbstractStably silenced genes that display a high level of CpG dinucleotide methylation are refractory to the current generation of dCas9-based activation systems. To counter this, we created an improved activation system by coupling the catalytic domain of DNA demethylating enzyme TET1 with transcriptional activators (TETact). TETact induces transcription of heavily suppressed non-coding RNA and surface protein, and the reactivation of embryonic haemoglobin genes in non-erythroid cells.

scholarly journals Molecular Subtype-Specific Expression of MicroRNA-29c in Breast Cancer Is Associated with CpG Dinucleotide Methylation of the Promoter

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0142224 ◽  
Author(s):  
Elizabeth Poli ◽  
Jing Zhang ◽  
Chika Nwachukwu ◽  
Yonglan Zheng ◽  
Babatunde Adedokun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Molecular Subtype ◽  
Specific Expression ◽  
Cpg Dinucleotide ◽  
Cpg Dinucleotide Methylation

scholarly journals Parvovirus B19 DNA CpG Dinucleotide Methylation and Epigenetic Regulation of Viral Expression

PLoS ONE ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. e33316 ◽  
Author(s):  
Francesca Bonvicini ◽  
Elisabetta Manaresi ◽  
Francesca Di Furio ◽  
Luisa De Falco ◽  
Giorgio Gallinella
Keyword(s):  
Epigenetic Regulation ◽  
Parvovirus B19 ◽  
Viral Expression ◽  
Cpg Dinucleotide ◽  
Cpg Dinucleotide Methylation
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