AbstractLet {\mathscr{R}} be a prime ring, {\mathscr{Q}_{r}} the right Martindale quotient ring of {\mathscr{R}} and {\mathscr{C}} the extended centroid of {\mathscr{R}}.
In this paper, we discuss the relationship between the structure of prime rings and the behavior of skew derivations on multilinear polynomials. More precisely, we investigate the m-potent commutators of skew derivations involving multilinear polynomials, i.e.,\big{(}[\delta(f(x_{1},\ldots,x_{n})),f(x_{1},\ldots,x_{n})]\big{)}^{m}=[%
\delta(f(x_{1},\ldots,x_{n})),f(x_{1},\ldots,x_{n})],where {1<m\in\mathbb{Z}^{+}}, {f(x_{1},x_{2},\ldots,x_{n})} is a non-central multilinear polynomial over {\mathscr{C}} and δ is a skew derivation of {\mathscr{R}}.