Interaction of Mn(II) and Zn(II) with ciprofloxacin antibiotics

The aim of this study is to check the redox behavior of Mn (II) and Zn (II) metals before and after interaction with ciprofloxacin in potassium chloride solution by using cyclic voltammetry, chronoamperomety and chronocoulometry methods. Equimolar solutions of Mn (II) and ciprofloxacin were mixed to a ratio of 1:2 and that of Zn (II) and ciprofloxacin to a 1:1 ratio. The results showed that the redox couple involved in Mn (II) as well as Mn(II)-ciprofloxacin interaction systems are quasi-reversible. However, the Zn (II) systems showed reversibility and the Zn(II)-ciprofloxacin interaction was quasi-reversible. The results obtained from the chronoamperometric study showed that after interaction with ciprofloxacin the rate of electrolysis in the metal systems decreased. Bangladesh J. Sci. Ind. Res.56(4), 285-292, 2021

Facile Synthesis and Redox Behavior of an Overcrowded Spirogermabifluorene

A spirogermabifluorene that bears sterically demanding 3,3′,5,5′-tetra(t-butyl)-2,2′-biphenylene groups (1) was obtained from the reaction of in-situ-generated 2,2′-dilithiobiphenylene with GeCl2·(dioxane). The solid-state structure and the redox behavior of 1 were examined by single-crystal X-ray diffraction analysis and electrochemical measurements, respectively. The sterically hindered biphenyl ligands endow 1 with high redox stability and increased electron affinity. The experimental observations were corroborated by theoretical DFT calculations.

Overhaul of the reducing ability of Breslow-type derivatives and implications for carbene-catalyzed radical reactions.

We report the synthesis of acyl azolium salts stemming from thiazolylidenes CNS, triazolylidenes CTN, mesoionic carbenes CMIC and the generation of their corresponding radicals and enolates, covering about 60 Breslow-type derivatives. This study highlights the role of additives in the redox behavior of these compounds and unveils several critical misconceptions about radical transformations of aldehyde derivatives under N-heterocyclic carbene catalysis. In particular, the reducing ability of enolates has been dramatically underestimated in the case of biomimetic CNS. In contrast with previous electrochemical studies, we show that these catalytic intermediates can transfer electrons to iodobenzene within minutes at room temperature. Enols derived from CMIC are not the previously claimed super electron donors, although enolate derivatives of CNS and CMIC are powerful reducing agents.