Detailed short-term follow-up high-resolution CT series of differentiation syndrome

A 57-year-old man with acute promyelocytic leukaemia (APML) received induction therapy including all-trans-retinoic acid (ATRA). At day 15, he developed dyspnoea, haemoptysis and hypoxia. Thorax CT demonstrated diffuse ground-glass opacity and consolidation predominantly in dorsal regions, which may reflect increased vascular permeability. He was diagnosed with differentiation syndrome. After dexamethasone was administered and chemotherapy suspended, his symptoms improved and abnormal lesions mostly disappeared on follow-up CT examinations. We report a short-term high-resolution CT series of differentiation syndrome.

Intestinal gangrene as the presenting manifestation of acute promyelocytic leukemia

Bleeding, often catastrophic, is common, however, thrombosis is rare in Acute Promyelocytic Leukemia (APL). Intestinal gangrene is an unusual presentation of thrombosis of mesenteric vasculature. We hereby, for the first time report this unusual presentation of intestinal gangrene secondary to leukaemic infiltration in APL and highlight the importance of prompt therapeutic intervention given its catastrophic nature. Keywords: Bowel; intestine; gangrene; acute promyelocytic leukaemia.