Investigation of tungsten heavy alloys using powder metallurgy technique

Recently, developing new alloys of Tungsten heavy (WHA) is the most important issue that researchers considered due to their wide applications of radiation protectors, vibration absorber, kinetic energy penetrators and heavy-duty electrical contacts. The present work shows 9 different Tungsten alloys with a variety of weight percent’s from "Graphene" as a Nano- particle additive. The proposed alloys produced by minimizing manufacturing parameters by applying the Taguchi technique. In addition, this work used to relate the Powder-Metallurgy (PM) parameters such as Sintering Temperature (ST) level, the weight % of the added Nano-particle of Graphene (Gw) and the type of Process Control Agent (PCA) with the mechanical characteristics such as Young’s modulus, modulus of Bulk, modulus of Shear, Poisson's number, Vickers hardness, Grain size , Relative Density. The results showed that specimen number 8 is given higher values of modulus of elasticity, reached 326.2 GPa, bulk value of 255.64 GPa, and shear value of 126.7 GPa with PM preparation condition at 15000C sintering temperature, stearic acid as a process control agent (PCA) and 0.0 %Wt. of Graphene.

Numerical Study of Free Convection inside the Differentially Heated Cavity incorporating Variable Property Al2O3-H2O Nanofluid

This paper investigates free convection in a partially heated square cavity filled with alumina-water nanofluid. The investigation is carried out at the three-volume fraction of nanoparticles (0, 0.03, 0.05), two Prandtl numbers (2.66, 6), and constant Grashof number (105) with three shapes of insulating obstacles (Square, Circular, and Rectangular). The results show that the nanofluid volume fraction and Prandtl number significantly enhance the heat transfer. The user-defined function (UDF) is developed and computed to investigate the effect of nanoparticle diameter and its temperature-dependent viscosity on convection. The average Nusselt number (Nu) increased with the temperature-dependent viscosity model and by increasing the percentage concentration of the nanoparticles. For all obstacle shapes, the thermal performance improved with increase in the nano-particle diameter.

Development of a SARS-CoV-2 Vaccine Candidate Using Plant-Based Manufacturing and a Tobacco Mosaic Virus-like Nano-Particle

Stable, effective, easy-to-manufacture vaccines are critical to stopping the COVID-19 pandemic resulting from the coronavirus SARS-CoV-2. We constructed a vaccine candidate CoV-RBD121-NP, which is comprised of the SARS-CoV-2 receptor-binding domain (RBD) of the spike glycoprotein (S) fused to a human IgG1 Fc domain (CoV-RBD121) and conjugated to a modified tobacco mosaic virus (TMV) nanoparticle. In vitro, CoV-RBD121 bound to the host virus receptor ACE2 and to the monoclonal antibody CR3022, a neutralizing antibody that blocks S binding to ACE2. The CoV-RBD121-NP vaccine candidate retained key SARS-CoV-2 spike protein epitopes, had consistent manufacturing release properties of safety, identity, and strength, and displayed stable potency when stored for 12 months at 2–8 °C or 22–28 °C. Immunogenicity studies revealed strong antibody responses in C57BL/6 mice with non-adjuvanted or adjuvanted (7909 CpG) formulations. The non-adjuvanted vaccine induced a balanced Th1/Th2 response and antibodies that recognized both the S1 domain and full S protein from SARS2-CoV-2, whereas the adjuvanted vaccine induced a Th1-biased response. Both adjuvanted and non-adjuvanted vaccines induced virus neutralizing titers as measured by three different assays. Collectively, these data showed the production of a stable candidate vaccine for COVID-19 through the association of the SARS-CoV-2 RBD with the TMV-like nanoparticle.