Background. Physical activity (PA) is a therapeutic approach to address post-secondary student mental health, yet the effect of PA on occupational outcomes has been understudied among students. Purpose. This study (1) identified and described occupational performance issues (OPIs) among post-secondary students seeking mental health support and (2) assessed pre- and post-intervention differences in occupational performance and performance satisfaction. Method. Using a single group pre-test post-test pilot study design, participants ( N = 20) completed a 6-week, 1-hour PA intervention. The Canadian Occupational Performance Measure was administered pre- and post-intervention. Findings. The most commonly reported OPIs included academics, PA, and sleep hygiene. There were significant improvements in participants’ occupational performance (mean change: 2.7, p < .001; dz = 2.28) and performance satisfaction (mean change: 3.7, p < .001; dz = 3.04). Implications. Results provide an initial demonstration of the benefits of PA for occupational outcomes within a post-secondary mental health context.