Progressive fatigue dynamic development of isolated natively musculus gastrocnemius medialis in alcoholic rats

In this article was investigated the development progressive fatigue dynamic of isolated natively musculus gastrocnemius medialis during tetanic contraction in alcoholic rats (n = 15). Registration of tetanic contraction of the isolated muscular preparation was registered in the isometric mode, during it’s direct electric stimulation. The results of research shows the absence of significant changes in isolated natively musculus gastrocnemius medialis development progressive fatigue in alcoholic rats, in comparison to intact animals.

Influence of C60FAS on the speed-power parameters of the tetanic contraction of muscle soleus on the conditions of experimentally-induced ischemia at different durations in alcoholised rats

In the article presented the results of tenzometric studies of the effect of C60FAS (concentration 0.15 mg / ml) at a dose of 1 mg / kg ON the speed-power parameters of the tetanic reduction of muscle soleus under conditions of ischemia in chronic alcoholic rats during 1-hour and 2-hour. The synergistic effect of ischemic injury and alcoholic intoxication, as compared to the native muscle, is manifested in reducing the reduction power to 26,25 ± 3,23 and 20,2 ± 2,45 (p≤0,01), and an increase in the time to achieve it the maximum values for 1.33 ± 0.12s and 1.45 ± 0.15s (p≤0.01) respectively. It is shown that if the intraperitoneal administration of the VRC60 solution is given, these indices are likely to increase.