pi kinase
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2016 ◽  
Vol 27 (7) ◽  
pp. 1170-1180 ◽  
Author(s):  
Deike J. Omnus ◽  
Andrew G. Manford ◽  
Jakob M. Bader ◽  
Scott D. Emr ◽  
Christopher J. Stefan

Membrane lipid dynamics must be precisely regulated for normal cellular function, and disruptions in lipid homeostasis are linked to the progression of several diseases. However, little is known about the sensory mechanisms for detecting membrane composition and how lipid metabolism is regulated in response to membrane stress. We find that phosphoinositide (PI) kinase signaling controls a conserved PDK-TORC2-Akt signaling cascade as part of a homeostasis network that allows the endoplasmic reticulum (ER) to modulate essential responses, including Ca2+-regulated lipid biogenesis, upon plasma membrane (PM) stress. Furthermore, loss of ER-PM junctions impairs this protective response, leading to PM integrity defects upon heat stress. Thus PI kinase–mediated ER-PM cross-talk comprises a regulatory system that ensures cellular integrity under membrane stress conditions.


2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 370.1-370
Author(s):  
M. Terajima ◽  
Y. Kaneko-Kobayashi ◽  
H. Mizuhara ◽  
T. Ishikawa ◽  
E. Imamura ◽  
...  

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Andrew Manford ◽  
Scott Emr ◽  
Christopher Stefan
Keyword(s):  

2013 ◽  
Vol 20 (7) ◽  
pp. 912-921 ◽  
Author(s):  
Xinming Cai ◽  
Yongyao Xu ◽  
Atwood K. Cheung ◽  
Ronald C. Tomlinson ◽  
Abel Alcázar-Román ◽  
...  

1998 ◽  
Vol 9 (5) ◽  
pp. 527-533 ◽  
Author(s):  
Christopher G. Burd ◽  
Markus Babst ◽  
Scott D. Emr

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