nmda receptor binding
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2021 ◽  
Vol 22 (10) ◽  
pp. 591-591
Author(s):  
Jake Rogers


Life Sciences ◽  
2021 ◽  
Vol 264 ◽  
pp. 118708
Author(s):  
Khadija Jalloh ◽  
Nicole Roeder ◽  
John Hamilton ◽  
Foteini Delis ◽  
Michael Hadjiargyrou ◽  
...  


2020 ◽  
Vol 23 (5) ◽  
pp. 311-318 ◽  
Author(s):  
Mark D Underwood ◽  
Mihran J Bakalian ◽  
Virginia L Johnson ◽  
Suham A Kassir ◽  
Steven P Ellis ◽  
...  

Abstract Background Glutamate is an excitatory neurotransmitter binding to 3 classes of receptors, including the N-methyl, D-aspartate (NMDA) receptor. NMDA receptor binding is lower in major depression disorder and suicide. NMDA receptor blocking with ketamine can have antidepressant and anti-suicide effects. Early-life adversity (ELA) may cause glutamate-mediated excitotoxicity and is more common with major depression disorder and in suicide decedents. We sought to determine whether NMDA-receptor binding is altered with suicide and ELA. Methods A total 52 postmortem cases were organized as 13 quadruplets of suicide and non-suicide decedents matched for age, sex, and postmortem interval, with or without reported ELA (≤16 years). Tissue blocks containing dorsal prefrontal (BA8), dorsolateral prefrontal (BA9), or anterior cingulate (BA24) cortex were collected at autopsy. Psychiatrically healthy controls and suicide decedents underwent psychological autopsy to determine psychiatric diagnoses and details of childhood adversity. NMDA receptor binding was determined by quantitative autoradiography of [3H]MK-801 binding (displaced by unlabeled MK-801) in 20-µm-thick sections. Results [3H]MK-801 binding was not associated with suicide in BA8, BA9, or BA24. However, [3H]MK-801 binding with ELA was less in BA8, BA9, and BA24 independent of suicide (P < .05). [3H]MK-801 binding was not associated with age or postmortem interval in any brain region or group. Conclusions Less NMDA receptor binding with ELA is consistent with the hypothesis that stress can cause excitotoxicity via excessive glutamate, causing either NMDA receptor downregulation or less receptor binding due to neuron loss consequent to the excitotoxicity.



2015 ◽  
Vol 1624 ◽  
pp. 239-252 ◽  
Author(s):  
Alec Lindsay Ward Dick ◽  
Tine Pooters ◽  
Sarah Gibbs ◽  
Emma Giles ◽  
Ashleigh Qama ◽  
...  


2015 ◽  
Vol 86 (10) ◽  
pp. 1150-1157 ◽  
Author(s):  
C J McGinnity ◽  
M J Koepp ◽  
A Hammers ◽  
D A Riaño Barros ◽  
R M Pressler ◽  
...  


PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0118721 ◽  
Author(s):  
Clark W. Bird ◽  
Felicha T. Candelaria-Cook ◽  
Christy M. Magcalas ◽  
Suzy Davies ◽  
C. Fernando Valenzuela ◽  
...  


Biology Open ◽  
2015 ◽  
Vol 4 (2) ◽  
pp. 125-136 ◽  
Author(s):  
L. Ning ◽  
S. Paetau ◽  
H. Nyman-Huttunen ◽  
L. Tian ◽  
C. G. Gahmberg


2015 ◽  
Vol 132 (2) ◽  
pp. 159-168 ◽  
Author(s):  
Manuela Mellone ◽  
Silvia Pelucchi ◽  
Lorenzo Alberti ◽  
Armando A. Genazzani ◽  
Monica Di Luca ◽  
...  




2013 ◽  
Vol 124 (6) ◽  
pp. 457-465 ◽  
Author(s):  
Qing Wang ◽  
Jin Li ◽  
Xiaobo Wei ◽  
Jinchi Liao ◽  
Yunqi Xu ◽  
...  


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