Chiral Monolithic Silica-Based HPLC Columns for Enantiomeric Separation and Determination: Functionalization of Chiral Selector and Recognition of Selector-Selectand Interaction

This review draws attention to the use of chiral monolithic silica HPLC columns for the enantiomeric separation and determination of chiral compounds. Properties and advantages of monolithic silica HPLC columns are also highlighted in comparison to conventional particle-packed, fused-core, and sub-2-µm HPLC columns. Nano-LC capillary monolithic silica columns as well as polymeric-based and hybrid-based monolithic columns are also demonstrated to show good enantioresolution abilities. Methods for introducing the chiral selector into the monolithic silica column in the form of mobile phase additive, by encapsulation and surface coating, or by covalent functionalization are described. The application of molecular modeling methods to elucidate the selector–selectand interaction is discussed. An application for enantiomeric impurity determination is also considered.

Investigating thermal bridging in window systems insulated with monolithic silica aerogel.

Windows typically account for 30% to 50% of heat losses through building envelopes. Monolithic silica aerogel has thermal properties and physical characteristics which make it an attractive material for high performance glazing. Optimizing the thermal performance of individual window components can improve the thermal performance of windows insulated with monolithic silica aerogel. It is important to consider how the thermal properties can be sustained, especially when in contact with other window components such as edge and intermediate spacers and the window frame. The purpose of this research paper is to analyze French style windows insulated with four panes of monolithic silica aerogel and investigate the thermal bridging of edge and intermediate spacers and window frame in order to assess how they collectively affect the centre of glass and edge of glass regions. The research aims to determine the spacer geometry, materials, and window frame that guarantee the best performing window system.

Investigating thermal bridging in window systems insulated with monolithic silica aerogel.

Windows typically account for 30% to 50% of heat losses through building envelopes. Monolithic silica aerogel has thermal properties and physical characteristics which make it an attractive material for high performance glazing. Optimizing the thermal performance of individual window components can improve the thermal performance of windows insulated with monolithic silica aerogel. It is important to consider how the thermal properties can be sustained, especially when in contact with other window components such as edge and intermediate spacers and the window frame. The purpose of this research paper is to analyze French style windows insulated with four panes of monolithic silica aerogel and investigate the thermal bridging of edge and intermediate spacers and window frame in order to assess how they collectively affect the centre of glass and edge of glass regions. The research aims to determine the spacer geometry, materials, and window frame that guarantee the best performing window system.