null cell adenoma
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2020 ◽  
Vol 21 (8) ◽  
pp. 2831 ◽  
Author(s):  
Shinsuke Uraki ◽  
Hiroyuki Ariyasu ◽  
Asako Doi ◽  
Ken Takeshima ◽  
Shuhei Morita ◽  
...  

Mismatch repair genes mutS homologs 6/2 (MSH6/2) expressions are involved in tumor growth and programmed cell death 1 ligand 1 (PD-L1) expression in tumor immunity, but the direct association with pituitary adenomas (PAs) is not well understood. We aimed to clarify the effects of MSH6/2 and PD-L1 expression on tumor proliferation and invasiveness in nonfunctioning (NF) PAs. We performed immunohistochemistry to classify the NFPAs into gonadotroph adenoma (GAs), silent corticotroph adenomas (SCAs), null cell adenoma (NCAs), and pituitary transcription factor 1 (PIT1) lineage PAs. We evaluated MSH6/2 and PD-L1 mRNA expressions in NFPAs by real-time PCR (n = 73), and statistically analyzed the expressions and clinicopathological factors. We also investigated the effect of MSH6 knockout on PD-L1 expression in AtT-20ins and GH3. MSH6/2 expressions were significantly lower in invasive NFPAs than in non-invasive NFPAs, and lower in SCAs and NCAs than in GAs. MSH6/2 expressions were positively associated with PD-L1 expression. PD-L1 expression was significantly lower in invasive NFPAs than in non-invasive NFPAs, and lower in SCAs and NCAs than in GAs. Although MSH6/2 expressions also tended to be lower in PIT1 lineage PAs than in GAs, PIT1 lineage PAs expressed PD-L1 equivalently to GA, which was unlike SCAs and NCAs. MSH6 knockout in AtT-20ins and GH3 significantly decreased PD-L1 expression (75% and 34% reduction, respectively) with cell proliferation promotion. In conclusion, differences in MSH6/2 and PD-L1 expressions of SCAs, NCAs, and PIT1-lineage PAs from those of GAs appear to contribute to their clinically aggressive characteristics, such as more proliferation and invasiveness.


2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Shousen Wang ◽  
Zhifeng Wu ◽  
Liangfeng Wei ◽  
Jianhe Zhang

2018 ◽  
Vol 13 (4) ◽  
pp. 677-680
Author(s):  
Vikram Singh ◽  
Kirti Gupta ◽  
Pravin Salunke ◽  
Sivashanmugam S. Dhandapani

2017 ◽  
Vol 78 (4) ◽  
pp. 314
Author(s):  
I. Bayar ◽  
Y. Hasni ◽  
A. Ben Abdelkrim ◽  
M. Kacem ◽  
M. Chaieb ◽  
...  

2014 ◽  
Vol 151 (1) ◽  
pp. 51-56 ◽  
Author(s):  
M.D. Chalkley ◽  
M. Kiupel ◽  
A.C.E. Draper

2014 ◽  
Vol 119 (2) ◽  
pp. 307-315 ◽  
Author(s):  
Jie Feng ◽  
Lichuan Hong ◽  
Yonggang Wu ◽  
Chuzhong Li ◽  
Hong Wan ◽  
...  

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