Matrix elasticity gradients guide neuronal polarity by controlling microtubule network mobility

Neuronal polarization and axon specification depend on extracellular cues, intracellular signaling, cytoskeletal rearrangements and polarized transport, but the interplay between these processes has remained unresolved. The polarized transport of kinesin-1 into a specific neurite is an early marker for axon identity, but the mechanisms that govern neurite selection and polarized transport are unknown. We show that extracellular elasticity gradients control polarized transport and axon specification, mediated by Rho-GTPases whose local activation is necessary and sufficient for polarized transport. Selective Kinesin-1 accumulation furthermore depends on differences in microtubule network mobility between neurites and local control over this mobility is necessary and sufficient for proper polarization, as shown using optogenetic anchoring of microtubules. Together, these results explain how mechanical cues can instruct polarized transport and axon specification.

A Case Study of Network Mobility (nemo-bsp) Integration with Leo Con-stellation System

Introduction: This manuscript is explicating the mutual compatibility of boot modes in a computer system and partition-ing styles of Hard Disk Drive. Most of us are familiar with these terms and know a little about these. Method: This manuscript contains the ample information about the boot modes of a computer system and partitioning styles of Hard Disk Drive (HDD) and their related configuration through which we get to know about their configuration and endurability. It also contains some practically verified case studies of the problems which occur due to the wrong con-figuration of boot modes and partitioning styles, though there are lot more but the most common ones are discussed along with their solutions. Result: In order to achieve the compatibility, it might require to convert the primary HDD into either GPT or MBR parti-tioning schemes. It should be marked that this interconversion wipes data on HDD, so cautiously the data on the hard drive must be backed-up before any conversion process. Conclusion: The information contained had been practically verified and is helpful in coping with the newer technology trends which contains more features along with backward compatibility. Keywords: Mobile IPv4, Mobile IPv6, NEMO, QoS, NS-2. Discussion: Right now passengers of flight are forced to interact with flight's pre-recorded entertainment system. Most of the passenger airlines do not allow a passenger to use the internet or any other type of interaction with the ground while during the flight. They force passengers to even switch their mobile to FLIGHT MODE so that there is no active commu-nication between a passenger and the remaining world.

Outbreak dynamics of COVID-19 in Europe and the effect of travel restrictions

ABSTRACTFor the first time in history, on March 17,2020, the European Union closed all its external borders to contain the spreading of the coronavirus 2019, COVID-19. Throughout two past months, governments around the world have implemented massive travel restrictions and border control to mitigate the outbreak of this global pandemic. However, the precise effects of travel restrictions on the outbreak dynamics of COVID-19 remain unknown. Here we combine a global network mobility model with a local epidemiology model to simulate and predict the outbreak dynamics and outbreak control of COVID-19 across Europe. We correlate our mobility model to passenger air travel statistics and calibrate our epidemiology model using the number of reported COVID-19 cases for each country. Our simulations show that mobility networks of air travel can predict the emerging global diffusion pattern of a pandemic at the early stages of the outbreak. Our results suggest that an unconstrained mobility would have significantly accelerated the spreading of COVID-19, especially in Central Europe, Spain, and France. Ultimately, our network epidemiology model can inform political decision making and help identify exit strategies from current travel restrictions and total lockdown.