Surmounting evidence supports that infectious agents play a critical role in shaping fish physiology, behaviour, and survival. The exclusion of disease-causing agents from fisheries research has resulted in major knowledge gaps that may limit the predictive capacity of ecological models. A major barrier in wild fisheries epidemiology is the logistical constraints associated with observing disease and obtaining samples from free-ranging fish, restricting the vast majority of research to laboratory studies or aquaculture facilities. For fisheries ecologists, including infectious agents can provide greater insight into observed phenomena, particularly with respect to fish physiology (e.g. metabolism), movement (e.g. migration rates), behaviour (e.g. habitat selection), personality (e.g. bold vs. shy), and survival. Here we provide a brief introduction to the current understanding of disease ecology in wild fish and describe technological advances in both epidemiology and fisheries and aquatic sciences that can be used in tandem to create comprehensive studies of disease ecology in wild fishes. Combining non-lethal sampling and molecular genetic-based identification methods with field studies creates vast opportunities for innovative study designs that have the potential to address the true complexity of aquatic ecosystems.