Correlation of in vivo imaging to morphomolecular pathology in translational research: challenge accepted

Correlation of in vivo imaging to histomorphological pathology in animal models requires comparative interdisciplinary expertise of different fields of medicine. From the morphological point of view, there is an urgent need to improve histopathological evaluation in animal model-based research to expedite translation into clinical applications. While different other fields of translational science were standardized over the last years, little was done to improve the pipeline of experimental pathology to ensure reproducibility based on pathological expertise in experimental animal models with respect to defined guidelines and classifications. Additionally, longitudinal analyses of preclinical models often use a variety of imaging methods and much more attention should be drawn to enable for proper co-registration of in vivo imaging methods with the ex vivo morphological read-outs. Here we present the development of the Comparative Experimental Pathology (CEP) unit embedded in the Institute of Pathology of the Technical University of Munich during the Collaborative Research Center 824 (CRC824) funding period together with selected approaches of histomorphological techniques for correlation of in vivo imaging to morphomolecular pathology.

Correlation of In Vivo Imaging To Morphomolecular Pathology In Translational Research – Challenge Accepted

Correlation of in vivo imaging to histomorphological pathology in animal models requires comparative interdisciplinary expertise of different fields of medicine. From the morphological point of view, there is an urgent need to improve histopathological evaluation in animal model based research to expedite translation into clinical applications. While different other fields of translational science were standardized over the last years, little was done to improve the pipeline of experimental pathology to ensure reproducibility based on pathological expertise in experimental animal models with respect to defined guidelines and classifications. Additionally, longitudinal analyses of preclinical models often use a variety of imaging methods and much more attention should be drawn to enable for proper co-registration of in vivo imaging methods with the ex vivo morphological read-outs. Here we present the development of the Comparative Experimental Pathology (CEP) unit embedded in the Institute of Pathology of the Technical University of Munich during the Collaborative Research Center 824 (CRC824) funding period together with selected approaches of histomorphological techniques for correlation of in vivo imaging to morphomolecular pathology.

The doctrine of neurons before the court of the newest researchers

The modern doctrine of neurons penetrated very quickly into the scientific consciousness of neurologists because of the clarity and definiteness of the basic provisions that clarify the pathways and methods of transmitting irritation in the nervous system. Based mainly on the Golgi method, it was, however, also consistent with the facts obtained using the methods of Gooden, Fleksig, Weigert, Marka as far as they concerned the course of nerve bundles; but the Golgi method had the advantage over the previous methods that it clarified the relationship of the nerve fiber to the cell and made it possible to follow the course and development of a particular fiber. In addition, the main provisions of this study were consistent with the development of nervous cells according to the research of Giss, with experimental physiology and clinical medicine, as well as with experimental pathology.