Preclinical Evaluation of Polymeric Nanocomposite Containing Pregabalin for Sustained Release as Potential Therapy for Neuropathic Pain

This study offers a novel oral pregabalin (PG)-loaded drug delivery system based on chitosan and hypromellose phthalate-based polymeric nanocomposite in order to treat neuropathic pain (PG-PN). PG-PN has a particle size of 432 ± 20 nm, a polydispersity index of 0.238 ± 0.001, a zeta potential of +19.0 ± 0.9 mV, a pH of 5.7 ± 0.06, and a spherical shape. Thermal and infrared spectroscopy confirmed nanocomposite generation. PG-PN pharmacokinetics was studied after a single oral dose in male Wistar rats. PG-PN showed greater distribution and clearance than free PG. The antinociceptive effect of PG-PN in neuropathic pain rats was tested by using the chronic constriction injury model. The parameter investigated was the mechanical nociceptive threshold measured by the von Frey filaments test; PG-PN showed a longer antinociceptive effect than free PG. The rota-rod and barbiturate sleep induction procedures were used to determine adverse effects; the criteria included motor deficit and sedative effects. PG-PN and free PG had plenty of motors. PG-PN exhibited a less sedative effect than free PG. By prolonging the antinociceptive effect and decreasing the unfavorable effects, polymeric nanocomposites with pregabalin have shown promise in treating neuropathic pain.

Hybrid Polymeric Nanocomposites Based High Performance Oleds: A Review

This review reports the recent significant progress for achieving the synthesis of various types of polymer-based nanocomposites and understanding of the basic principle which determine their optical, electronic and magnetic properties. Some of the polymeric nanocomposite materials show remarkable electrical as well as optical properties regarding towards interest for applications in OLEDs. Nanoparticles which are basically inorganic, plays important role in the opto-electronic field. A nanoparticle with conjugate polymer matrix makes polymer nanocomposite and that nanocomposite used as an active emissive layer between the structures of optoelectronic device like OLEDs, OPVs etc. Application of such polymeric nanocomposite materials are discussed in this present communication with their success and failure, towards their optical as well as electrical properties in the fabrication of OLEDs.