Effect of solution acidity on the structure of amino acid-bearing uranyl compounds

A series of uranyl sulfates and selenates templated by protonated forms of amino acids (glycine, α- and β-alanine, threonine, nicotinic, and isonicotinic acid) has been prepared via isothermal evaporation of strongly acidic solutions. Their structures have been refined by the direct methods and can be classified as inorganic [(UO2)m(TO4)n (H2O)k] (T=S6+, Se6+) moieties combined with the protonated amino acid cations, water molecules and hydronium ions. Their overall motifs demonstrate common features with related structures templated by organic amines. The role of carboxylic acid groups depends on the nature of the corresponding amino acid. They can either link two protonated organic moieties into dimers, or contribute to hydrogen bonding between organic and inorganic parts of the structure. The ammonium ends of the amino acid cations form strong directional bonds to the oxygens of the uranyl and TO4 anions.

Articular Cartilage: The Destruction of Bilayers and Deactivation of Phospholipid Molecules

To our knowleadge the coaugulation by interacton of β2 -Glycoprotein I (β2 -GP I) with the phospholipid membrane is required to verify this hypothesis. The open hockey stick-like conformation occurs when protonated amino acid functional group (-NH3 +) β2-GP I is complexed to negatively charged phospholipids functional group (-PO4 - ) resulting in the destruction of bilayers and the deactivation of phospholipid molecules.

Molecular recognition of isomeric protonated amino acid esters monitored by ESI-mass spectrometry

Two new 9,9’-spirobifluorene-derived crown ethers were prepared and used to recognise constitutionally isomeric amino acid derivatives. The performance of the receptors was evaluated by ESI-mass spectrometry using the isomer labelled guest method (ILGM). This method revealed the preferred binding of L-norleucine and L-leucine compared to L-isoleucine for both receptors. Furthermore, non-covalent isotope effects demonstrate the relevance of dispersive interactions for the overall binding event. These effects also provide hints for the relative spatial orientation of the guest molecules within the host–guest complex, and thereby prove the importance of the spirobifluorene moiety for the observed binding of the protonated amino acid esters.