Molecular recognition of isomeric protonated amino acid esters monitored by ESI-mass spectrometry
2014 ◽
Vol 10
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pp. 825-831
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Keyword(s):
Two new 9,9’-spirobifluorene-derived crown ethers were prepared and used to recognise constitutionally isomeric amino acid derivatives. The performance of the receptors was evaluated by ESI-mass spectrometry using the isomer labelled guest method (ILGM). This method revealed the preferred binding of L-norleucine and L-leucine compared to L-isoleucine for both receptors. Furthermore, non-covalent isotope effects demonstrate the relevance of dispersive interactions for the overall binding event. These effects also provide hints for the relative spatial orientation of the guest molecules within the host–guest complex, and thereby prove the importance of the spirobifluorene moiety for the observed binding of the protonated amino acid esters.
2021 ◽
Vol 66
(11)
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pp. 1616-1620
2006 ◽
Vol 255-256
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pp. 301-311
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2015 ◽
Vol 51
(11)
◽
pp. 1642-1648
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1986 ◽
Vol 153
(2)
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pp. 372-379
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2013 ◽
Vol 17
(17)
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pp. 1903-1909
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Keyword(s):