cerebral tumours
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2021 ◽  
Vol 28 (1) ◽  
pp. 863-872
Author(s):  
Anna Lena Hohneck ◽  
Stephanie Rosenkaimer ◽  
Ralf-Dieter Hofheinz ◽  
Ibrahim Akin ◽  
Martin Borggrefe ◽  
...  

Cardiovascular (CV) diseases and cancer share several similarities, including common risk factors. In the present investigation we assessed the relationship between cholesterol levels and mortality in a cardiooncological collective. In total, 551 patients receiving anticancer treatment were followed over a median of 41 (95% CI 40, 43) months and underwent regular cardiological surveillance. A total of 140 patients (25.4%) died during this period. Concomitant cardiac diseases were more common in patients who deceased (53 (37.9%) vs. 67 (16.3%), p < 0.0001), as well as prior stroke. There were no differences in the distribution of classical CV risk factors, such as hypertension, diabetes or nicotine consumption. While total cholesterol (mg/dL) was significantly lower in patients who deceased (157 ± 59 vs. 188 ± 53, p < 0.0001), both HDL and LDL cholesterol were not differing. In addition, cholesterol levels varied between different tumour entities; lowest levels were found in patients with tumours of the hepatopancreaticobiliary system (median 121 mg/dL), while patients with melanoma, cerebral tumours and breast cancer had rather high cholesterol levels (median > 190 mg/dL). Cholesterol levels were significantly lower in patients who died of cancer; lowest cholesterol levels were observed in patients who died of tumours with higher mitotic rate (mesenchymal tumours, cerebral tumours, breast cancer). Cox regression analysis revealed a significant mortality risk for patients with stem cell transplantation (HR 4.31) and metastasised tumour stages (HR 3.31), while cardiac risk factors were also associated with a worse outcome (known cardiac disease HR 1.58, prior stroke/TIA HR 1.73, total cholesterol HR 1.70), with the best discriminative performance found for total cholesterol (p = 0.002).


Author(s):  
Elena Claudia Covaci ◽  
Simona Dumitra ◽  
Carmen Cri&scedil;an ◽  
Ozana B&acaron;lan ◽  
Carmen St&acaron;ncule&tcedil; ◽  
...  

2017 ◽  
Vol 19 (suppl_1) ◽  
pp. i25-i25
Author(s):  
Ms Manon Simard ◽  
Dr James R. Larkin ◽  
Mr Kevin J. Ray ◽  
Dr Alexandre A. Khrapitchev ◽  
Dr James A. Meakin ◽  
...  

Author(s):  
Kai Ritschel ◽  
Ioannis Pechlivanis ◽  
Christian Kensy ◽  
Rasmus Risse ◽  
Susanne Winter

2013 ◽  
Vol 1 ◽  
pp. 29-33
Author(s):  
Paweł Sokal ◽  
Andrzej Lebioda ◽  
Maciej Harat ◽  
Jacek Furtak ◽  
Monika Grzela ◽  
...  

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