This chapter studies how immigration policy can be deployed as a key instrument of grand strategy, a site where state actors might use the levers of immigrant and refugee admissions to advance both a comprehensive and integrated set of social, economic, and security goals at home. Indeed, a diverse array of US presidents, lawmakers, and activists have had grand strategies in mind as they pursued major immigration reform. The chapter focuses on a particularly significant effort to remake the US immigration system—the 1960s struggle to dismantle national origins quotas and reopen US gates to immigrants and refugees—in order to illustrate the possibilities and limitations of grand strategizing in this policy realm. One can discern these dynamics in immigration reforms and executive actions from the 1920s to the present, but the successful battle for the Immigration and Nationality Act of 1965 provides an especially illuminating example. Before turning to this case, however, the chapter first considers immigration control and grand strategy in the early American republic and the rise of rival interests and ideals that make significant policy innovation contingent on incongruous coalitions and uneasy compromises.