This chapter surveys the dominant modes of interpreting the Revelation in the Middle Ages. Attention is given to the influence of the older Latin commentaries by Victorinus and Tyconius on medieval exegesis, and to the ways in which the patristic perspectives were appropriated by early medieval commentators such as Primasius, Beatus, Bede, Alcuin, and Haimo. The tradition continued to be adapted through new interpretive methods in twelfth-century commentaries, such as the one ascribed to “Berengaudus” and that of Richard of St. Victor. The interpretation by Rupert of Deutz, followed by Anselm of Havelberg and, especially, Joachim of Fiore interpreted Revelation in terms of broader conceptions of history. Finally, attention is given to the continued development of historical perspectives by writers of the thirteenth and fourteenth centuries, including Alexander Minorita, Peter John Olivi, and Nicolas of Lyra.