P.131 Outcomes of Nusinersen in adult and pediatric cohorts of spinal muscular amyotrophy after two years of usage at the CHU de Québec-Université Laval

Background: Nusinersen is approved for spinal muscular amyotrophy type I,II,III and is available for adult and pediatric populations since January 2019 at the CHU de Québec-UL. Methods: Patients who received at least one dose of nusinersen between January 2019 and March 2021 were included. Required information was gathered from patients’ charts. Results: Ten adults (70 injections) and 23 infants and children (202 injections) were included. No child but two adults stopped the therapy for personal reasons. Tests were performed at 0, 6, 18, 24 months when possible to assess efficacy, tolerability and quality of life perception (Table 1). Preliminary data shows stabilization or improvement for many tests. Conclusions: Nusinersen is well tolerated. Favorable effects were observed in both populations. A monitoring is still imperative for an objective assessment and for evaluation of the most relevant tests. Long term benefits remain to be demonstrated but results are encouraging.

Photographic views taken in Egypt and Nubia by James Douglas, M.D. and James Douglas Jr.

This thesis focuses on the 19th century albums Photographic Views Taken in Egypt, which hold photographs and text by James Douglas, M.D. (1800-1886) and his son James Douglas Jr. (1837-1918). The albums are held in the collections of the Archive of Modern Conflict (AMC), Toronto, Canada, the British Library, London, England, The Brooklyn Museum’s Wilbour Library of Egyptology Special Collections in Brooklyn, New York City, and Université Laval in Quebec City, Quebec, Canada. The albums are also identified as Photographic Views Taken in Nubia and Photographic Views of Egypt & Nubia and include views of both Egypt and Nubia. Since the albums were privately printed for friends and family, little research and academic discussion has taken place on them. This thesis strives to resolve this gap in academic discussion and has begun a discourse on Photographic Views Taken in Egypt.

Photographic views taken in Egypt and Nubia by James Douglas, M.D. and James Douglas Jr.

This thesis focuses on the 19th century albums Photographic Views Taken in Egypt, which hold photographs and text by James Douglas, M.D. (1800-1886) and his son James Douglas Jr. (1837-1918). The albums are held in the collections of the Archive of Modern Conflict (AMC), Toronto, Canada, the British Library, London, England, The Brooklyn Museum’s Wilbour Library of Egyptology Special Collections in Brooklyn, New York City, and Université Laval in Quebec City, Quebec, Canada. The albums are also identified as Photographic Views Taken in Nubia and Photographic Views of Egypt & Nubia and include views of both Egypt and Nubia. Since the albums were privately printed for friends and family, little research and academic discussion has taken place on them. This thesis strives to resolve this gap in academic discussion and has begun a discourse on Photographic Views Taken in Egypt.

Evaluation of the feasibility and impacts of in situ simulation in emergency medicine—a mixed-method study protocol

IntroductionIn situ simulation (ISS) consists of performing a simulation in the everyday working environment with the usual team members. The feasibility of ISS in emergency medicine is an important research question, because ISS offers the possibility for repetitive, regular simulation training consistent with specific local needs. However, ISS also raises the issue of safety, since it might negatively impact the care of other patients in the emergency department (ED). Our hypothesis is that ISS in an academic high-volume ED is feasible, safe and associated with benefits for both staff and patients.MethodsA mixed-method, including a qualitative method for the assessment of feasibility and acceptability and a quantitative method for the assessment of patients’ safety and participants’ psychosocial risks, will be used in this study.Two distinct phases are planned in the ED of the CHU de Québec-Université Laval (Hôpital de l’Enfant-Jésus) between March 2021 and October 2021. Phase 1: an ISS programme will be implemented with selected ED professionals to assess its acceptability and safety and prove the validity of our educational concept. The number of cancelled sessions and the reasons for cancellation will be collected to establish feasibility criteria. Semistructured interviews will evaluate the acceptability of the intervention. We will compare unannounced and announced ISS. Phase 2: the impact of the ISS programme will be measured with validated questionnaires for the assessment of psychosocial risks, self-confidence and perceived stress among nonselected ED professionals, with comparison between those exposed to ISS and those that were not.Ethics and disseminationThe CHU de Québec-Université Laval Research ethics board has approved this protocol (#2020–5000). Results will be presented to key professionals from our institution to improve patient safety. We also aim to publish our results in peer-reviewed journals and will submit abstracts to international conferences to disseminate our findings.

Tailleurs de pierre : entre l’art et la matière

Les métiers traditionnels liés à l’architecture gagnent à être mis en valeur et à être reconnus pour leurs apports inégalés dans la protection et la conservation du patrimoine bâti. Parmi ces métiers, celui de tailleur de pierre fait écho à des techniques, des savoir-faire, une histoire ancestrale et une longue évolution dans le temps, qui méritent d’être mis à l’avant-scène. Dans cet article, on propose un retour critique sur un projet de collaboration entre une équipe d’étudiants en études patrimoniales (Université Laval) et le tailleur de pierre Adrien Bobin qui a mené aux développements de plusieurs stratégies de promotion du métier traditionnel et de transmission des connaissances à son sujet. En passant par la cocréation, la médiation culturelle, les technologies numériques et la mise en exposition muséale, on verra qu’une collaboration entre de jeunes chercheurs en patrimoine et des artisans du patrimoine bâti constitue une voie remplie de potentiel pour faire connaître ces métiers sans les dénaturer.