nitric oxide delivery
Recently Published Documents


TOTAL DOCUMENTS

139
(FIVE YEARS 12)

H-INDEX

29
(FIVE YEARS 0)

2021 ◽  
pp. 2103449
Author(s):  
Shun Yao ◽  
Yuetong Wang ◽  
Junjie Chi ◽  
Yunru Yu ◽  
Yuanjin Zhao ◽  
...  




2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Dashuai Zhu ◽  
Jingli Hou ◽  
Meng Qian ◽  
Dawei Jin ◽  
Tian Hao ◽  
...  

AbstractNitric oxide (NO) is a short-lived signaling molecule that plays a pivotal role in cardiovascular system. Organic nitrates represent a class of NO-donating drugs for treating coronary artery diseases, acting through the vasodilation of systemic vasculature that often leads to adverse effects. Herein, we design a nitrate-functionalized patch, wherein the nitrate pharmacological functional groups are covalently bound to biodegradable polymers, thus transforming small-molecule drugs into therapeutic biomaterials. When implanted onto the myocardium, the patch releases NO locally through a stepwise biotransformation, and NO generation is remarkably enhanced in infarcted myocardium because of the ischemic microenvironment, which gives rise to mitochondrial-targeted cardioprotection as well as enhanced cardiac repair. The therapeutic efficacy is further confirmed in a clinically relevant porcine model of myocardial infarction. All these results support the translational potential of this functional patch for treating ischemic heart disease by therapeutic mechanisms different from conventional organic nitrate drugs.







2021 ◽  
Vol 66 (6) ◽  
pp. 1021-1028
Author(s):  
Stefano Gianni ◽  
Ryan W Carroll ◽  
Robert M Kacmarek, ◽  
Lorenzo Berra


Author(s):  
Zhi Lin ◽  
Rosana V. Pinto ◽  
Carlos Henriques ◽  
Fernando Antunes ◽  
João Pires ◽  
...  




Author(s):  
Joana Claudio Pieretti ◽  
Marcelly Chue Gonçalves ◽  
Gerson Nakazato ◽  
Ana Carolina Santos de Souza ◽  
Ariane Boudier ◽  
...  

AbstractThe combination of Fe3O4@Ag superparamagnetic hybrid nanoparticles and nitric oxide (NO) represents an innovative strategy for a localized NO delivery with a simultaneous antibacterial and antitumoral actions. Here, we report the design of Fe3O4@Ag hybrid nanoparticles, coated with a modified and nitrosated chitosan polymer, able to release NO in a biological medium. After their synthesis, physicochemical characterization confirmed the obtention of small NO-functionalized superparamagnetic Fe3O4@Ag NPs. Antibacterial assays demonstrated enhanced effects compared to control. Bacteriostatic effect against Gram-positive strains and bactericidal effect against E. coli were demonstrated. Moreover, NO-functionalized Fe3O4@Ag NPs demonstrated improved ability to reduce cancer cells viability and less cytotoxicity against non-tumoral cells compared to Fe3O4@Ag NPs. These effects were associated to the ability of these NPs act simultaneous as cytotoxic (necrosis inductors) and cytostatic compounds inducing S-phase cell cycle arrest. NPs also demonstrated low hemolysis ratio (<10%) at ideal work range, evidencing their potential for biomedical applications.





Sign in / Sign up

Export Citation Format

Share Document