The thermodynamic analysis of a ceramic compound solubility was carried out for ceramic compounds which may be used for dispersion hardening of advanced nickel alloys. The thermodynamic description of stability conditions was completed for a disperse heterophase systems consists of metal melt – nanosize phases (NSP). For a thermodynamic criterion (К) of stability was selected the specific variation of a free energy of the process of a disperse system degradation (referred to change of unit of a surface phases contact). The analysis was executed in view of formation of thick and thin elastic wetting films and takes in account a disjoining pressure. The above definition of new thermodynamically rigorous criterions becomes physically real, if the isotherm of a disjoining pressure is measured. The derived criterions are simplified in the Young approximation. In this case the criterion are expressed through measurable interfacial performances - interfacial tension and wetting angles. The application of a stability condition gives a simple outcome: aggregation of NSP does not happen at a wetting angles ≤ 600. On a basis of own experimental data the evaluations are carried out for possibility of using of some compounds as exogenous modifiers of a nickel alloys. The example of dispersion hardening of high-temperature strength nickel alloy and improving its heat resisting properties is reduced.
