Significance of Inorganic Nitrate Supplement in Cardiovascular Health

Background amp; Objectives: Nitric Oxide (NO) is frequently produced by the enzyme Nitric Oxide Synthase (NOS) and is crucial to the control and effective ness of the cardiovascular system. However, there is substantial reduction in NOS activity with aging that can lead to the development of hypertension and other cardiovascular obstacles. Fortunately, NO can also being produced by sequential reduction of inorganic nitrates supplementation. This proves that NO from inorganic nitrate supplements can provide compensation when NOS activity is inadequate and cardio protective benefits and beyond that provided by healthy NOS system. Discussion: This review focus on the general information about Nitrous oxide, types, mechanism of action of NO & overview of NOS activity is inadequate and cardio protective benefits and beyond that provided by healthy NOS system were often studied for cardiovascular treatments. Conclusion: We concluded that the Natural plant NO is the essential for cardiovascular activity to target site with desired concentration. Moreover, the researchers were focused on Evidence suggested that nitrate supplementation can help regulate blood pressure, limit progression of atherosclerosis, and improve myocardial contractility in both healthy individuals and those with cardiovascular disease.

Operation of Large RF Driven Negative Ion Sources for Fusion at Pressures below 0.3 Pa

The large (size: 1 m × 2 m) radio frequency (RF) driven negative ion sources for the neutral beam heating (NBI) systems of the future fusion experiment ITER will be operated at a low filling pressure of 0.3 Pa, in hydrogen or in deuterium. The plasma will be generated by inductively coupling an RF power of up to 800 kW into the source volume. Under consideration for future neutral beam heating systems, like the one for the demonstration reactor DEMO, is an even lower filling pressure of 0.2 Pa. Together with the effect of neutral gas depletion, such low operational pressures can result in a neutral gas density below the limit required for sustaining the plasma. Systematic investigations on the low-pressure operational limit of the half-ITER-size negative ion source of the ELISE (Extraction from a Large Ion Source Experiment) test facility were performed, demonstrating that operation is possible below 0.2 Pa. A strong correlation of the lower pressure limit on the magnetic filter field topology is found. Depending on the field topology, operation close to the low-pressure limit is accompanied by strong plasma oscillations in the kHz range.