EVALUATION OF THE GENERAL TOXIC PROPERTIES OF A NEW ANTISEPTIC AND DISINFECTANT FOR VETERINARY USE

The article presents data on the toxicological properties of the disinfectant, which includes alkyldimethylammonium propyl ketone chloride, glutaraldehyde, glyoxal. Based on the results of a series of experiments, the main parameters of the toxicity of the disinfectant were determined. For male mice, the acute toxicity LD50 was 325±14.5 mg / kg, for male rats – 350±50 mg/kg, according to the classification of GOST 12.1.007-76, the agent belongs to the 3rd hazard class. The LD50 with repeated administration of the drug was 217±13.5 mg/kg of animal weight, the cumulation coefficient was 0.67, which indicates the ability of the drug with repeated intragastric administration to accumulate in the body of animals.

Influence of the solvent donor number on the O/W partition ratio of Cu(II) complexes of 1,2-dialkylimidazoles

Extraction experiments are presented dealing with the partition of Cu(II) complexes of 1-alkyl-2-methylimidazoles, 1-alkyl-2-ethylimidazoles, 1-alkyl-2-propylimidazoles, 1-alkyl-2-butylimidazoles, and 1-alkyl-2-pentylimidazoles (where alkyl = ethyl, butyl, hexyl) between water and an immiscible organic solvent (chloroform, methylene chloride, 2-ethylhexanol, isoamyl alcohol, benzyl alcohol, methyl propyl ketone, and toluene). It has been shown that the partition ratios of Cu(II) complexes are dependent on the donor number (DN) of the solvent and the partition ratios increase distinctly with their increase in DN.