dna nanostructures
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2022 ◽  
Vol 74 ◽  
pp. 278-284
Author(s):  
Elizabeth Jergens ◽  
Jessica O Winter
Keyword(s):  

Nano Letters ◽  
2022 ◽  
Author(s):  
Giacomo Fabrini ◽  
Aisling Minard ◽  
Ryan A. Brady ◽  
Marco Di Antonio ◽  
Lorenzo Di Michele
Keyword(s):  

Author(s):  
Raghu Pradeep Narayanan ◽  
Leeza Abraham

Abstreact: DNA nanotechnology marvels the scientific world with its capabilities to design, engineer, and demonstrate nanoscale shapes. This review is a condensed version walking the reader through the structural developments in the field over the past 40 years starting from the basic design rules of the double-stranded building block to the most recent advancements in self-assembled hierarchically achieved structures to date. It builds off from the fundamental motivation of building 3-dimensional (3D) lattice structures of tunable cavities going all the way up to artificial nanorobots fighting cancer. The review starts by covering the most important developments from the fundamental bottom-up approach of building structures, which is the ‘tile’ based approach covering 1D, 2D, and 3D building blocks, after which, the top-down approach using DNA origami and DNA bricks is also covered. Thereafter, DNA nanostructures assembled using not so commonly used (yet promising) techniques like i-motifs, quadruplexes, and kissing loops are covered. Highlights from the field of dynamic DNA nanostructures have been covered as well, walking the reader through the various approaches used within the field to achieve movement. The article finally concludes by giving the authors a view of what the future of the field might look like while suggesting in parallel new directions that fellow/future DNA nanotechnologists could think about.


2022 ◽  
Author(s):  
Shaokang Ren ◽  
Keith Fraser ◽  
Lili Kuo ◽  
Neha Chauhan ◽  
Addison T. Adrian ◽  
...  

2022 ◽  
Vol 8 (1) ◽  
Author(s):  
Richard Kosinski ◽  
Joel Mieres Perez ◽  
Elisa-C. Schöneweiß ◽  
Yasser B. Ruiz-Blanco ◽  
Irene Ponzo ◽  
...  

2022 ◽  
Author(s):  
Yao Xu ◽  
Shu-wei Huang ◽  
Yu-qiang Ma ◽  
Hong-ming Ding

With the rapid development of nanotechnology, various DNA nanostructures have been synthesized and widely used in the drug delivery. However, the underlying mechanisms of drug molecules loading into the DNA...


Author(s):  
Matthew Chiriboga ◽  
Sebastian A. Diaz ◽  
Divita Mathur ◽  
David A. Hastman ◽  
Joseph S. Melinger ◽  
...  

Author(s):  
Alexander L. Danesi ◽  
Dimitra Athanasiadou ◽  
Abdulmateen O. Aderinto ◽  
Prakash Rasie ◽  
Leo Y. T. Chou ◽  
...  

2021 ◽  
Author(s):  
Chuan Jiang ◽  
Biao Lu ◽  
Wei Zhang ◽  
Yoel P. Ohayon ◽  
Feiyang Feng ◽  
...  

The overwinding and underwinding of duplex segments between junctions have been used in designing both left-handed and right-handed DNA origami nanostructures. For a variety of DNA tubes obtained from self-assembled tiles, only a theoretical approach of the intrinsic curvature of the DNA tile (specified as the intrinsic tile curvature) has been previously used to explain their formation. Details regarding the quantitative and structural descriptions of the tile curvature and its evolution in DNA tubes by the coupling of the twist of the inter-tile arm (specified as the arm twist) have never been addressed. In this work, we designed three types of tile cores built around a circular 128 nucleotide scaffold by using longitudinal weaving (LW), bridged longitudinal weaving (bLW) and transverse weaving (TW). Joining the tiles with inter-tile arms having the length of an odd number of DNA half-turns (termed O-tiling) almost resulted into planar 2D lattices, whereas joining the tiles with the arms having the length of an even number of DNA half-turns (termed E-tiling) nearly generated tubes. Streptavidin bound to biotin was used as a labeling technique to characterize the inside and outside surfaces of the E-tiling tubes and thereby the conformations of their component tiles with addressable concave and convex curvatures. When the arms have the normal winding at the relaxed B-form of DNA, the intrinsic tile curvature deter-mines the chirality of the E-tiling tubes. By regulating the arm length and the sticky end length of the bLW-Ep/q (E-tiling of the bLW cores with the arm length of p-bp and the sticky end length of q-nt) assemblies, the arm can be overwound, resulting in a left-handed twist, and can also be underwound, resulting in a right-handed twist. Chiral bLW-Ep/q tubes with either a right-handed curvature or a left-handed curvature can also be formed by the coupling of the intrinsic tile curvature and the arm twist. We were able to assign the chiral indices (n,m) to each tube using high-resolution AFM images, and therefore were able to estimate the tile curvature using a regular polygon model that approximated the transverse section of the tube. A deeper understanding of the integrated actions of dif-ferent types of twisting forces on the DNA tubes will be extremely helpful in engineering more elaborate DNA nanostructures in the future.


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