Immuno-Histochemical and Morphometric Characteristics NPY-Positive Neurons of the Different Fields of Human Cerebral Cortex at the Chronical Ischemia

mmuno-histochemical (NPY - neuropeptide Y) and morphometric study of the distribution and architectonics of NPY immune-positive brakes of interneurons layer III of various fractions (field 4, 10, 17 and 21) of neocortex human normal (n=5) and chronic ischemia (n=15, perhifocal area tumors) was carried out. Verification of NPY-positive brake interneurons held on the content of NPY, the shape of their bodies and processes. In all studied fields in norm and under ischemia the basket cells, Martinotti cells and releasing secret of inter-neurons were identified. It was established that in case of chronic ischemia in all the studied fields cortex of the relative size of NPY-immune-positive structures (labelled bodies of neurons and their appendages) are statistically significantly higher than in control: in field 10 - in 1.95, in field 4 - 1,85, in field 21 - 2,17, in field 17 - 2,15 times. The received results testify to a compensatory increase in the expression of NPY in the intact interneurons of perifocal area of human neocortex with chronic ischemia. Increase in the volume of NPY- immune-positive material was due to the expansion and thickening of the processes of interneurons. The authors examine the hypothesis about the possible role of activation and hypertrophy of NPY- immune-positive interneurons in the regulation of the balance of brake systems and exciting damaged brain cortex and as one of the mechanisms for the protection of neural networks from chronic ischemic damage.

Clinico-electrophysiological analysis of family cases with heredited neuropathy and predisposition to compression paralyses

Clinico-electrophysiological analysis of the most common in Russia family selection, having a particular form of demyelinization neuropathy hereditary neuropathy with predisposition to compression paralyses (HNPCP) has been presented. In all the families the diagnosis has been confirmed with the help of DNA diagnostics, based upon revealing of typical deletion in chromosome field 17.p.11.2. Besides a classical recurrent variant some other phenotypes of the disease have been described: recurrent positional sensoric symtoms, progressing mononeuropathy, progressing polyneuropathy. Electrophysiological signs have been determined, which are the most informative for HNPCP. These signs can used for clinical diagnostics of the disease followed by DNA diagnostics. Relative incidence of this special form of neuropathy among acquired compression mononeuropathies (6%) and their recurrent variants (50%) has been counted.

REACTION OF NON-CULTIVATED OATS FROM ISRAEL TO CANADIAN RACES OF CROWN RUST AND STEM RUST

Two hundred and two collections of non-cultivated oats from Israel, belonging to Avena sterilis L. and A. barbata Brot., were tested in the greenhouse at Winnipeg, Manitoba, for seedling and adult plant reaction to several important crown rust and stem rust races. Seeds of the collections found resistant in the greenhouse to one of the test races were planted in the field and were exposed to artificial rust epidemics. Out of 123 collections of A. sterilis, 40 were resistant to crown rust in the greenhouse and 9 remained resistant in the field; one collection was resistant to stem rust in the greenhouse but none was resistant in the field. Out of 79 collections of A. barbata, 23 were resistant to crown rust in the greenhouse and 8 maintained resistance in the field; 17 collections were resistant to stem rust in the greenhouse and 8 were resistant in the field.Crown rust and stem rust resistance factors seem to be independent of each other; the plants of only a few collections possessed resistance to both rusts. Collection D203 was particularly outstanding, showing resistance to all the test races of crown rust and stem rust in seedling and adult stages in the greenhouse as well as in the field.