Effect of quercetin on parenchymatous organ of the alloxan induced diabetes in male rats

Background: Diabetes is directly involved in oxidative stress production. Therefore, this work was conducted to investigate the histopathological changes which occur in parenchymatous and to evaluate the antioxidant effect of quercetin in alloxan induced diabetes in male albino rats.Methods: Thirty-six male albino rats were divided into six groups of 6 rats in each group and treated as follows: a control group, quercetin group, diabetic control group, diabetic with quercetin group, diabetic with insulin group, diabetic with quercetin plus insulin group, alloxan was administered as a single dose (140 mg/kg body weight) to induce diabetes.Results: Result showed histopathological changes which included degenerative to necrotic changes of the liver, kidney and pancreas and this are due to the effect of oxidative stress that occurred from diabetes by alloxan. Conversely, quercetin significantly modulated improved histopathological changes founded on this study with or without of insulin, furthermore, results showed that damaged tissues where improved when groups of rats treated with quercetin and insulin together.Conclusions: It has been concluded that the quercetin could be promising antioxidants for reducing the risk of oxidation induced by diabetes that lead to nephrotoxicity, hepatotoxicity and pancreatic damage.

MORPHOLOGICAL STUDIES IN EXPERIMENTAL CRETINISM

In summarizing the findings of this paper it may be said that degenerative changes have been noted in practically every parenchymatous organ. Among these the most striking has been that of serous imbibition by the most active cells of these organs. In regard to the changes in the glands of internal secretion, the findings corroborate the statements of Cushing in regard to hypophysectomy, that removal of one gland of internal secretion results in changes in all the other glands. In this case, degenerative changes predominate in the hypophysis, thymus, ovary, and testis, while hyperplasia is seen in the islands of Langerhans and the medullas of the adrenal glands. Finally, in the rabbit athyroidism is responsible for grave degenerative changes in practically all organs and tissues of the body, and many of the symptoms of cretinism have an anatomical basis in organic cellular changes.