Molecular Interactions and Aggregation Behavior of Cloxacillin Sodium in Water and Aqueous NaCl Solutions through Volumetric and Ultrasonic Sound Velocity Studies at 298.15 KMolecular Interactions and Aggregation Behavior of Cloxacillin Sodium in Water and Aqueous NaCl Solutions through Volumetric and Ultrasonic Sound Velocity Studies at 298.15 K

Molecular interactions and aggregation behavior of cloxacillin sodium (CloNa) in water and aqueous NaCl solutions was studied through volumetric and ultrasonic sound velocity method at 298.15 K and atmospheric pressure. Density, ρ, and ultrasonic sound velocity, u, of cloxacillin sodium in water and aqueous NaCl solutions were measured with a digital density and ultrasonic sound velocity analyzer (DSA 5000, Anton Paar, Austria). And from the investigational data, apparent molar volume, ϕn, adiabatic compressibility, ϕS, apparent molar adiabatic compressibility, ϕk, limiting apparent molar volume, ϕn0, limiting apparent molar adiabatic compressibility, ϕk0, and aggregation concentration, CMC of cloxacillin sodium was calculated. The outcomes indication exhibits very significant evidence about the interactions among solute-solvent-co-solute (solute-solute, solute-solvent) and aggregation behavior in the aqueous environment and this result would be useful for the drug action in human body with pharmacological applications.

Volumetric and Ultrasonic Velocity Studies of Urea and Thiourea in Aqueous Solution

The observations on the anomalous behavior of urea and the comparison between urea and thiourea in aqueous solutions have been examined by volumetric and ultrasonic sound velocity techniques at different temperature (298.15, 303.15, 308.15, 313.15, 318.15 and 323.15 K) , atmospheric pressure by using a high accuracy vibrating U-tube digital density and ultrasonic sound velocity analyzer. The apparent molar volume (ϕv) & apparent molar adiabatic compressibility (ϕk) have been calculated from experimental density and ultrasonic sound velocity data respectively and limiting apparent molar volume (ϕv0), limiting apparent molar adiabatic compressibility (ϕk0) have been evaluated from apparent molar volume vs. molality plot as intercept. Apparent molar expansibility (ϕE) was determined from apparent molar volume and hydration number (nH) from adiabatic compressibility. The results show very interesting information about strong solute-solvent & solute-solute interactions, and also elaborate the structure making or breaking behavior in the solution mixtures.