Using Volumetric Method the Study of Molecular Interactions of NSAID (DP) in Water and Water + 1M Urea at Different Temperatures

Understanding possible interactions of drugs and the factors that command such interactions could be helpful to control their disadvantageous effects upon human health. In this study, volumetric properties for the solution of diclofenac potassium (DP), a non-steroidal anti-inflammatory drug (NSAID), were investigated for the first time to look into its molecular interactions at four different temperatures varying from 298.15 K to 313.15 K at 5 K intervals in water as well as aqueous hydrotropic agent urea (1M) solutions. Experimental density data obtained using a pycnometer have been taken to estimate apparent molar properties, i.e., limiting apparent molar volume (〖V_ɸ〗^0), apparent molar volume (V_ɸ), limiting apparent molar expansibility (〖E_ɸ〗^0) and apparent molar expansibility (E_ɸ). The results obtained were discussed in terms of solute-solvent and solute-solute interactions in the studied systems. The obtained results from volumetric data were explored in terms of the existence of solute-solvent interactions in aqueous systems of drug solutions.

Solvodynamic study on Solubility Enhanced Lovastatin in presence of Arginine as Cosolute

In this study, the solute-cosolute interaction, solute-solvent interaction involved in the solubilisation process of ARG solutions and LVS-ARG solution systems are illustrated. The sound velocity values of both solution systems were determined at varying concentrations of ARG (0.01-0.8 mol.dm-3) at 298.15 K. Next, the refractive index and the density of the solution systems was measured at temperature range from 298.15 to 313.15K. Acoustic and volumetric parameters such as isentropic compressibility (KS), apparent isentropic molar compressibility (KSΦ), relative association (RA), acoustic impedance (Z), internal pressure (πi), free volume (Vf), molar volume (Φv0), molar expansibility (ΦE0) were calculated from sound velocity and density data. From the study, an increasing trend in sound velocity was observed with the increase in ARG concentration while compressibility values showed opposite trend. Additionally, solute-solvent interaction and structural effects of water for ARG and LVS-ARG systems are discussed regarding the changes in acoustic parameters.

Interactions of Drug Doxycycline Hyclate with Galactitol in Aqueous Solutions at Different Temperatures by Volumetric and Acoustic Methods

The experimental values of density, ρ and speed of sound, u of doxycycline hyclate drug (0.002–0.014) mol kg−1 in water and (0.1, 0.2 and 0.4) mol kg−1 of aqueous galactitol solutions at temperatures T = (303.15, 308.15 and 313.15) K and at atmospheric pressure have been reported in the present communication. From the experimental values, various derived parameters such as apparent molar volume (ΦV), apparent molar isentropic compression (ΦK), limiting apparent molar volume ($\phi_{\text{v}}^{\text{o}}$), limiting apparent molar isentropic compression ($\phi_{\text{K}}^{\text{o}}$), limiting apparent molar volume of transfer (Δ$\phi_{\text{V}}^{\text{O}}$), limiting apparent molar isentropic compression of transfer (Δ$\phi_{\text{K}}^{\text{O}}$), limiting apparent molar expansibility ($\phi_{\text{E}}^{\text{o}}$), thermal expansion coefficient (α) and acoustic parameters like isentropic compressibility $({{\kappa}_{\text{S}}})$, intermolecular free length (Lf), and specific acoustic impedance (Z) were calculated. The structure-making behaviour of DH in aqueous galactitol solution was determined on the basis of Hepler’s Equation i.e. on the basis of sign of ${\left({\frac{{{{\text{d}}^{2}}\phi_{\text{V}}^{\text{O}}}}{{{\text{d}}{{\text{T}}^{2}}}}}\right)_{\text{P}}}$. The various derived parameters were utilised to interpret the molecular interactions i.e. solute–solute and solute–solvent existing in the studied system.

A Comparative Study on the Effect of Temperature and Concentration on Density, Sound Velocity and their Derived Properties for Diclofenac Potassium in Aqueous Urea Media

The present study has undertaken experimental measurements of ultrasonic velocity (U) and density (d) of solutions of Diclofenac potassium in water and in aqueous urea media of different molar concentrations. Computation of physico-chemical parameters like apparent molar volume (V_Φ), limiting apparent molar volume (V_Φ^0 ), apparent molar expansibility (E_Φ), limiting apparent molar expansibility (E_Φ^0 ), molar isentropic compressibility (K_s), apparent molar isentropic compressibility(K_(s,ɸ) ),molar adiabatic compressibility (W), molar isothermal compressibility (K_T), acoustic impedance (Z), free volume (V_f ), internal pressure (π_i), relative association (R_A), coefficient of thermal expansion (α) and van der Waals constant (b) was done by using the experimentally obtained values. The influence of varying concentrations of Diclofenac potassium as well as of urea in solutions and the variation of the investigating temperatures on the above mentioned parameters are expected to reveal the nature of different molecular interactions existing in the drug solutions.

Study of Molecular Interaction for Antibiotic Drug with Sugar Solutions at Different Temperature

The interactions of drug amoxicillin with maltose or galactose solutions with a variation of temperature have been discussed by taking in the volumetric and viscometric procedures. Physical properties [densities (ρ) and viscosities (η)] of amoxicillin (AMOX) aqueous solutions and aqueous solutions of two type saccharides (maltose and galactose 0.05m) have been measured at T = (298.15, 303.15 and 308.15) K under atmospheric pressure. The apparent molar volume (ϕv cm3mole-1) has been evaluated from density data and fitted to a Redlich-Mayer equation. The empirical parameters of the Mayer-Redlich equation and apparent molar volume at infinite dilution Ø°v were explicated in terms of interactions from type solute-solvent and solute–solute interactions. Transfer molar volume ΔtraØ°v for AMOX from water to aqueous maltose and galactose solutions were calculated to comprehend different interactions in the ternary solutions. Limiting apparent molar expansibility (Ø°E) and Hepler’s coefficient was also calculated to indicate the structure making ability of AMOX in the ternary solutions. Jones–Dole coefficient B and A have been calculated from viscosity data by employing the Jones–Dole equation. The free energy of activation of viscous flow per mole of the solute (Δμ°2*) and solvent (Δμ°1*) have been explained on the basis of the Eyring and Feakins equation.

Volumetric and Ultrasonic Velocity Studies of Urea and Thiourea in Aqueous Solution

The observations on the anomalous behavior of urea and the comparison between urea and thiourea in aqueous solutions have been examined by volumetric and ultrasonic sound velocity techniques at different temperature (298.15, 303.15, 308.15, 313.15, 318.15 and 323.15 K) , atmospheric pressure by using a high accuracy vibrating U-tube digital density and ultrasonic sound velocity analyzer. The apparent molar volume (ϕv) & apparent molar adiabatic compressibility (ϕk) have been calculated from experimental density and ultrasonic sound velocity data respectively and limiting apparent molar volume (ϕv0), limiting apparent molar adiabatic compressibility (ϕk0) have been evaluated from apparent molar volume vs. molality plot as intercept. Apparent molar expansibility (ϕE) was determined from apparent molar volume and hydration number (nH) from adiabatic compressibility. The results show very interesting information about strong solute-solvent & solute-solute interactions, and also elaborate the structure making or breaking behavior in the solution mixtures.

Volume properties of dilute aqueous solutions of poly(oxyethylene) and its low molecular models

The densities were measured of pure liquid mono-, di-, tri-, and poly(oxyethylene) up to the molar mass 20 000, of 3-oxa-1-butanol and 3,6-dioxa-1-heptanol, 3-oxa-1-pentanol and 3,6-dioxa-1-octanol, 3,6-dioxa-1-decanol, 2,5-dioxahexane, 2,5,8,11-tetraoxadodecane and 2,5,8,11,14-pentaoxapentadecane, 3,6-dioxaoctane and 3,6,9-trioxaundecane and their aqueous solutions at the mass concentrations smaller than 0.02 in the temperature range 15-50 °C. The experimental data thus obtained were used to calculate values of the apparent specific volume at infinite dilution, specific expansion at infinite dilution, excess limiting partial specific volume and excess limiting molar expansibility of the dissolved compound. The suitability of these values as criteria of hydrophobicity of the respective compounds was verified. The volume contributions of homologous and end groups were calculated.