run and tumble
Recently Published Documents


TOTAL DOCUMENTS

112
(FIVE YEARS 54)

H-INDEX

23
(FIVE YEARS 7)

Pramana ◽  
2021 ◽  
Vol 95 (4) ◽  
Author(s):  
Aradhana Kumari ◽  
Sourabh Lahiri
Keyword(s):  

2021 ◽  
Author(s):  
Benjamin Partridge ◽  
Sara Gonzalez Anton ◽  
Reema Khorshed ◽  
George Adams ◽  
Constandina Pospori ◽  
...  

Multi-potent progenitor (MPP) cells act as a key intermediary step between haematopoietic stem cells and the entirety of the mature blood cell system. Their eventual fate determination is thought to be achieved through migration in and out of spatially distinct niches. Here we first analyze statistically MPP cell trajectory data obtained from a series of long time-course 3D in-vivo imaging experiments on irradiated mouse calvaria, and report that MPPs display transient super-diffusion with apparent non-Gaussian displacement distributions. Second, we explain these experimental findings using a run-and-tumble model of cell motion which incorporates the observed dynamical heterogeneity of the MPPs. Third, we use our model to extrapolate the dynamics to time-periods currently inaccessible experimentally, which enables us to quantitatively estimate the time and length scales at which super-diffusion transitions to Fickian diffusion. Our work sheds light on the potential importance of motility in early haematopoietic progenitor function.


eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Yang Bai ◽  
Caiyun He ◽  
Pan Chu ◽  
Junjiajia Long ◽  
Xuefei Li ◽  
...  

Coordination of diverse individuals often requires sophisticated communications and high-order computational abilities. Microbial populations can exhibit diverse individualistic behaviors, and yet can engage in collective migratory patterns with a spatially sorted arrangement of phenotypes. However, it is unclear how such spatially sorted patterns emerge from diverse individuals without complex computational abilities. Here, by investigating the single-cell trajectories during group migration, we discovered that, despite the constant migrating speed of a group, the drift velocities of individual bacteria decrease from the back to the front. With a Langevin-type modeling framework, we showed that this decreasing profile of drift velocities implies the spatial modulation of individual run-and-tumble random motions, and enables the bacterial population to migrate as a pushed wave front. Theoretical analysis and stochastic simulations further predicted that the pushed wave front can help a diverse population to stay in a tight group, while diverse individuals perform the same type of mean reverting processes around centers orderly aligned by their chemotactic abilities. This mechanism about the emergence of orderly collective migration from diverse individuals is experimentally demonstrated by titration of bacterial chemoreceptor abundance. These results reveal a simple computational principle for emergent ordered behaviors from heterogeneous individuals.


2021 ◽  
Vol 104 (4) ◽  
Author(s):  
Pierre Le Doussal ◽  
Satya N. Majumdar ◽  
Grégory Schehr
Keyword(s):  

Author(s):  
Benjamin De Bruyne ◽  
Satya N Majumdar ◽  
Gregory Schehr
Keyword(s):  

Sign in / Sign up

Export Citation Format

Share Document