This is the first time to synthesize naphthylamine from one-step naphthalene amination by vanadium catalysts with high yield under mild condition. It could obtain ∼70% yield of naphthylamine, with major product of valuable 1,5-diaminonaphthalene.
The multiple reaction
monitoring mode of a triple quadrupole mass spectrometer is used to examine the
Buchwald-Hartwig amination reaction at 0.1% catalyst loading in real-time using
sequential addition of reagents to probe the individual steps in the cycle. This
is a powerful new method for probing reactions under realistic conditions.
